Diabetes and vascular disease.
Diabetes and vascular disease.
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DOI：
10.1586/14779072.6.1.127
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Srikanth, Sundararajan
中科院分区：
文献类型：
--
作者：
Deedwania, Prakash;Srikanth, Sundararajan
2型糖尿病已达到流行病的程度，现在被认为是冠心病的等价物。虽然与糖尿病相关的最常见的代谢异常是高血糖症，但也存在碳水化合物、脂肪和蛋白质代谢的异常。这些异常增加了氧化应激并激活了肾素-血管紧张素系统，导致内皮功能障碍，随后导致全身性动脉粥样硬化。这种系统性动脉粥样硬化是糖尿病相关的心血管发病率和死亡率增加的原因。在这篇文章中，我们回顾了证据，并讨论了全面降低风险的基本原理，以预防和治疗糖尿病患者的血管疾病。综合风险降低策略的组成部分包括改变生活方式、控制血糖、控制血脂异常和高血压。
Type 2 diabetes has reached epidemic proportions and is now recognized as a coronary heart disease equivalent. While the most common metabolic abnormality associated with diabetes is hyperglycemia, there are also abnormalities in carbohydrate, fat and protein metabolism. These abnormalities increase oxidative stress and activate the renin-angiotensin system leading to endothelial dysfunction and, thereafter, to systemic atherosclerosis. This systemic atherosclerosis is responsible for the increased cardiovascular morbidity and mortality related to diabetes. In this article, we review the evidence and discuss the rationale for comprehensive risk reduction to prevent and treat vascular disease in individuals with diabetes mellitus. The components of comprehensive risk reduction strategy consist of lifestyle changes, glycemic control, control of dyslipidemia and hypertension.