Functionally distinct high and low theta oscillations in the human hippocampus
Functionally distinct high and low theta oscillations in the human hippocampus
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DOI：
10.1038/s41467-020-15670-6
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发表时间：
2020-05-18
影响因子：
16.6
通讯作者：
Jacobs, Joshua
中科院分区：
文献类型：
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作者：
Goyal, Abhinav;Miller, Jonathan;Jacobs, Joshua
基于啮齿动物模型，研究人员推测海马通过θ振荡支持情景记忆和导航，θ振荡类似于4-10 Hz的节奏，协调全脑神经活动。然而，来自人类的记录表明，海马体θ振荡的频率较低，并且比啮齿动物更不普遍，这表明θ功能的物种间差异。为了表征人类海马theta的特征，我们在神经外科受试者执行虚拟空间导航任务时检查了整个海马前后长度的theta振荡的特性。在虚拟运动过程中，我们观察到海马振荡在多个频率从2到14赫兹。后海马突出地显示出类似于8 Hz的振荡，这些振荡的精确频率与运动速度相关，暗示这些信号在空间导航中。我们还观察到类似于3 Hz的较慢振荡，但这些信号在前海马中更普遍，并且它们的频率不随运动速度而变化。我们的研究结果与最近的研究结果一致，提出了人类海马电生理学的最新观点。而不是一个海马θ振荡与一个单一的一般作用，高和低频率θ振荡，分别反映了空间和非空间的认知过程。我们发现，人类海马体在空间导航过程中表现出两种不同的θ振荡，其中后区的振荡更快，显示出运动调制。这一结果表明，与啮齿动物相比，人类海马体具有明显的特征，啮齿动物通常表现出单一的8 Hz节律。
Based on rodent models, researchers have theorized that the hippocampus supports episodic memory and navigation via the theta oscillation, a similar to 4-10 Hz rhythm that coordinates brain-wide neural activity. However, recordings from humans have indicated that hippocampal theta oscillations are lower in frequency and less prevalent than in rodents, suggesting interspecies differences in theta's function. To characterize human hippocampal theta, we examine the properties of theta oscillations throughout the anterior-posterior length of the hippocampus as neurosurgical subjects performed a virtual spatial navigation task. During virtual movement, we observe hippocampal oscillations at multiple frequencies from 2 to 14Hz. The posterior hippocampus prominently displays oscillations at similar to 8-Hz and the precise frequency of these oscillations correlates with the speed of movement, implicating these signals in spatial navigation. We also observe slower similar to 3Hz oscillations, but these signals are more prevalent in the anterior hippocampus and their frequency does not vary with movement speed. Our results converge with recent findings to suggest an updated view of human hippocampal electrophysiology. Rather than one hippocampal theta oscillation with a single general role, high- and low-frequency theta oscillations, respectively, may reflect spatial and non-spatial cognitive processes. We show that the human hippocampus exhibits two distinct theta oscillations during spatial navigation with the faster oscillation in posterior regions showing movement modulation. This result suggests a distinct feature of the human hippocampus compared to rodents, which generally show a single 8 Hz rhythm.