ALTERED PLATELET PROTEIN-KINASE-C ACTIVITY IN BIPOLAR AFFECTIVE-DISORDER, MANIC EPISODE
ALTERED PLATELET PROTEIN-KINASE-C ACTIVITY IN BIPOLAR AFFECTIVE-DISORDER, MANIC EPISODE
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DOI：
10.1016/0006-3223(93)90006-y
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发表时间：
1993-04-01
影响因子：
10.6
通讯作者：
SINGH, H
中科院分区：
文献类型：
--
作者：
FRIEDMAN, E;WANG, HY;SINGH, H
在锂治疗前和治疗期间，研究了双相情感障碍受试者血小板中蛋白激酶C（PKC）活性和PKC易位对5-羟色胺的反应。躁狂症患者血小板膜结合蛋白激酶C活性与胞浆蛋白激酶C活性的比值升高。此外，在这些受试者中，发现阿托伐他汀引起的血小板PKC易位增强。锂治疗长达2周导致细胞溶质和膜相关的PKC活性减少，并在一个衰减的PKC易位，以响应血清素。这些初步结果表明，血小板PKC的改变与双相情感障碍的躁狂相有关。结果还表明，锂处理降低了血小板对5-羟色胺-2受体激活诱导的PKC易位的敏感性。
Protein kinase C (PKC) activity and PKC translocation in response to serotonin were investigated in platelets obtained from bipolar affective disorder subjects before and during lithium treatment. Ratios of platelet membrane-bound to cytosolic PKC activities were elevated in the manic subjects. In addition, serotonin-elicited platelet PKC translocation was found to be enhanced in those subjects. Lithium treatment for up to 2 weeks resulted in a reduction in cytosolic and membrane-associated PKC activities and in an attenuated PKC translocation in response to serotonin. These preliminary results suggest that alteration in platelet PKC is associated with the manic phase of bipolar illness. The results also suggest that lithium treatment reduces the sensitivity of platelets to PKC translocation induced by activation of serotonin-2 receptors.