CHROMOSOME STUDIES IN PRELEUKEMIA .3. MYELOFIBROSIS
CHROMOSOME STUDIES IN PRELEUKEMIA .3. MYELOFIBROSIS
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DOI：
10.1002/1097-0142(197611)38:5
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发表时间：
1976-01-01
期刊：
影响因子：
6.2
通讯作者：
GERMAN, J
中科院分区：
文献类型：
--
作者：
NOWELL, P;JENSEN, J;GERMAN, J
对18例骨髓纤维化或与之密切相关的未分化骨髓增生性疾病(MPD)患者进行了细胞遗传学研究。在8个人的血液中发现了染色体异常的细胞克隆，其中2人有放射治疗史，2人有急性骨髓纤维化。后2例患者存在8三体，但在其他情况下，没有一致的细胞遗传学模式或与特定血液学结果相关。其中16名患者被随访超过1年或直至死亡；没有一名患者进展为白血病。结果表明，染色体异常在本病中相对常见，但与真性红细胞增多症不同，与其他一些白血病前期状态不同，骨髓纤维化中的异常克隆并不意味着临床白血病即将到来。
Cytogenetic studies were done in 18 patients with myelofibrosis or the closely related syndrome, undifferentiated myeloproliferative disorder (MPD). Clones of cells with chromosome abnormalities were demonstrated in the blood of 8 individuals, including 2 with a history of radiation therapy and 2 with acute myelofibrosis. Trisomy 8 was present in the latter 2 patients, but otherwise, there was no consistent cytogenetic pattern or correlation with specific hematologic findings. Sixteen of these patients were followed for more than 1 yr or until death; none has progressed to leukemia. The results indicate that chromosome abnormalities are relatively common in this disorder, but as with polycythemia vera, and unlike some other preleukemic states, the aberrant clones in myelofibrosis do not appear to indicate that clinical leukemia is imminent.