Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment.
Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment.
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DOI：
10.1016/j.tcb.2015.08.009
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发表时间：
2015-12
影响因子：
19
通讯作者：
Howard J
中科院分区：
文献类型：
--
作者：
Bowne-Anderson H;Hibbel A;Howard J
Recent studies have found that microtubule-associated proteins (MAPs) can regulate the dynamical properties of microtubules in unexpected ways. For most MAPs, there is an inverse relationship between their effects on the speed of growth and the frequency of catastrophe, the conversion of a growing microtubule to a shrinking one. Such a negative correlation is predicted by the standard GTP-cap model, which posits that catastrophe is due to loss of a stabilizing cap of GTP-tubulin at the end of a growing microtubule. However, many other MAPs, notably Kinesin-4 and combinations of EB1 with XMAP215, contradict this general rule. In this review, we show that a more nuanced, but still simple, GTP-cap model, can account for the diverse regulatory activities of MAPs.
