Serum ferritin levels in anemia of rheumatoid arthritis.
Serum ferritin levels in anemia of rheumatoid arthritis.
复制标题
类风湿性关节炎贫血中的血清铁蛋白水平。
作者：
R. Smith;P. Davis;A. Thomson;L. Wadsworth;P. Fackre
对35例类风湿性关节炎贫血患者进行了研究，以确定血清铁蛋白水平和体内铁状态之间的关系，通过骨髓铁储备的分级进行评估。骨髓铁储备明显减少或缺失的发生率为60%。外周血涂片、红细胞指数、血清铁和铁结合力与骨髓铁相关性较差。血清铁蛋白水平仅与铁储存有关，缺铁类风湿患者的水平高于单纯缺铁患者的水平。该研究表明，骨髓铁储备减少在类风湿性关节炎患者中很常见，血清铁蛋白浓度可以提供这些受试者体内铁储备减少的有用指示，但前提是可以为这种疾病建立一系列正常值。
Thirty-five anemic patients with rheumatoid arthritis were studied to determine the relationship between serum ferritin levels and body iron status, as assessed by the grading of bone marrow iron stores. The incidence of greatly reduced or absent marrow iron stores was 60%. Peripheral blood smear, RBC indices, serum iron, and iron binding capacity correlated poorly with stainable marrow iron. Serum ferritin levels only correlated approximately with iron stores, and in iron deficient rheumatoid patients the levels were higher than would be expected in patients with uncomplicated iron deficiency. The study shows that reduced marrow iron stores is common in patients with rheumatoid arthritis, and that the serum ferritin concentration may provide a useful indication of reduced body iron stores in these subjects, but only if a range of normal values can be established for this disease.