Enantioselective Construction of Pyrimidine-Fused Diazepinone Derivatives Bearing a Tertiary Stereogenic Center Enabled by Iridium-Catalysed Intramolecular Allylic Substitution
Enantioselective Construction of Pyrimidine-Fused Diazepinone Derivatives Bearing a Tertiary Stereogenic Center Enabled by Iridium-Catalysed Intramolecular Allylic Substitution
复制标题
铱催化分子内烯丙基取代对映选择性构建带有三级立构中心的嘧啶稠合二氮杂酮衍生物
DOI：
10.1002/adsc.202100444
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发表时间：
2021
影响因子：
5.4
通讯作者：
Qiu Liqin
中科院分区：
文献类型：
--
作者：
Jiang Xiaoding;Pan Bendu;Qian Xu;Liang Hao;Zhang Yaqi;Chen Bin;He Xiaobo;Chan Hoi Shan;Chan Albert S. C.;Qiu Liqin
发展了铱催化的嘧啶系烯丙基碳酸酯的分子内烯丙基取代反应。成功地构建了一系列手性嘧啶-稠合二氮杂卓酮衍生物，产率为88-96%，ees为85-99%。这项工作进一步强调了手性桥联联苯亚磷酰胺在不对称合成中的作用。
The iridium‐catalysed enantioselective intramolecular allylic substitution of pyrimidine‐tethered allylic carbonates was developed. A wide range of chiral pyrimidine‐fused diazepinone derivatives were successfully constructed in 88–96% yields with 85–99% ees. This work further highlights the power of chiral‐bridged biphenyl phosphoramidites in asymmetric synthesis.