1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.
1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.
复制标题
1-氨基-APDC，II 类代谢型谷氨酸受体的部分激动剂，具有神经保护特性。
DOI：
10.1016/s0960-894x(99)00266-8
复制
发表时间：
1999
影响因子：
2.7
通讯作者：
Wroblewski,JT
中科院分区：
文献类型：
--
作者：
Kozikowski,AP;Araldi,GL;Tückmantel,W;Pshenichkin,S;Surina,E;Wroblewski,JT
The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.
