Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway.
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway.
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DOI：
10.1016/j.cellsig.2010.03.017
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发表时间：
2010-09
影响因子：
4.8
通讯作者：
Chen LF
中科院分区：
文献类型：
--
作者：
Huang B;Yang XD;Lamb A;Chen LF
真核转录因子NF-κB调节多种宿主基因，这些基因控制炎症和免疫反应、程序性细胞死亡、细胞增殖和分化。NF-κB的活化在细胞质和细胞核中都受到严格控制。虽然NF-κB激活的上游胞质调控事件已被充分研究，但对NF-κB的核调控知之甚少。新出现的证据表明，NF-κB经历了各种翻译后修饰，并且这些修饰在决定NF-κB核活性的持续时间和强度以及其转录输出中起关键作用。本文就NF-κB的翻译后修饰、各种修饰之间的相互作用以及这些修饰的生理意义等方面的最新进展进行综述。
The eukaryotic transcription factor NF-κB regulates a wide range of host genes that control the inflammatory and immune responses, programmed cell death, cell proliferation and differentiation. The activation of NF-κB is tightly controlled both in the cytoplasm and in the nucleus. While the upstream cytoplasmic regulatory events for the activation of NF-κB are well studied, much less is known about the nuclear regulation of NF-κB. Emerging evidence suggests that NF-κB undergoes a variety of posttranslational modifications, and that these modifications play a key role in determining the duration and strength of NF-κB nuclear activity as well as its transcriptional output. Here we summarize the recent advances in our understanding of the posttranslational modifications of NF-κB, the interplay between the various modifications, and the physiological relevance of these modifications.
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影响因子：
11.4
作者：
Duran, A;Diaz-Meco, MT;Moscat, J
通讯作者：
Moscat, J
DOI：
10.1158/1078-0432.ccr-09-1352
发表时间：
2009-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Arun P;Brown MS;Ehsanian R;Chen Z;Van Waes C
通讯作者：
Van Waes C
影响因子：
4.8
作者：
Buss, H;Dörrie, A;Kracht, M
通讯作者：
Kracht, M
影响因子：
5.3
作者：
Dai, Y;Rahmani, M;Grant, S
通讯作者：
Grant, S
影响因子：
64.8
作者：
Chen, FE;Huang, DB;Ghosh, G
通讯作者：
Ghosh, G