Role of glutathione in immunity and inflammation in the lung.
Role of glutathione in immunity and inflammation in the lung.
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DOI：
10.2147/ijgm.s15618
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发表时间：
2011-01-25
影响因子：
2.3
通讯作者：
Ghezzi P
中科院分区：
文献类型：
--
作者：
Ghezzi P
活性氧和硫醇抗氧化剂，包括谷胱甘肽（GSH），在不同水平上调节先天免疫。这篇综述概述了与炎症和宿主防御感染有关的细胞机制的氧化还原敏感步骤，并描述了谷胱甘肽不仅作为抗氧化剂而且作为信号分子的重要性。关于谷胱甘肽在免疫中的作用有大量的文献。大多数评论都被一种过于简单化的观点所偏见，即“坏的”自由基会导致各种疾病，而“好的”抗氧化剂则能预防它们并防止氧化应激。虽然在某些领域（如毒理学）可能是这样，但硫醇（本综述的主题）在免疫中的作用当然需要戴上科学家的眼镜，并准备接受更复杂的情况。这篇综述旨在描述GSH在免疫和炎症的背景下在肺中的作用。第一部分概述了这幅画的历史和基本概念。第二部分关注谷胱甘肽代谢/病理水平，第三部分关注谷胱甘肽在先天免疫和炎症中的作用，第四部分给出4个例子，描述谷胱甘肽在感染反应中的重要性。
Reactive oxygen species and thiol antioxidants, including glutathione (GSH), regulate innate immunity at various levels. This review outlines the redox-sensitive steps of the cellular mechanisms implicated in inflammation and host defense against infection, and describes how GSH is not only important as an antioxidant but also as a signaling molecule. There is an extensive literature of the role of GSH in immunity. Most reviews are biased by an oversimplified picture where “bad” free radicals cause all sorts of diseases and “good” antioxidants protect from them and prevent oxidative stress. While this may be the case in certain fields (eg, toxicology), the role of thiols (the topic of this review) in immunity certainly requires wearing scientist’s goggles and being prepared to accept a more complex picture. This review aims at describing the role of GSH in the lung in the context of immunity and inflammation. The first part summarizes the history and basic concepts of this picture. The second part focuses on GSH metabolism/levels in pathology, the third on the role of GSH in innate immunity and inflammation, and the fourth gives 4 examples describing the importance of GSH in the response to infections.