Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases.
Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases.
复制标题
DOI：
10.1292/jvms.15-0310
复制
发表时间：
2016-07-01
期刊：
影响因子：
--
通讯作者：
Tamura Y
中科院分区：
文献类型：
--
作者：
Furusawa T;Iwano H;Higuchi H;Yokota H;Usui M;Iwasaki T;Tamura Y
铜绿假单胞菌是一种病原体，经常被确定为各种感染或慢性疾病的原因。这种微生物对几种抗生素具有天然抗性，因为该物种的外膜，外排泵和生物膜生长。这种细菌可以通过特定的点突变获得增加的抗性。然而，噬菌体（噬菌体）可以裂解这些细菌。因此，在本研究中，我们评估了铜绿假单胞菌分离株的宿主范围及其裂解耐药铜绿假单胞菌的能力。本品能裂解多种铜绿假单胞菌（28/39），其中包括对氟喹诺酮类药物高度耐药的铜绿假单胞菌（4/6）。总之，应用抗生素对耐药菌是非常有效的。为了避免普遍的抗药性细菌，需要进一步开发用于疾病治疗的噬菌体用途。
Pseudomonas aeruginosa is a pathogen frequently identified as the cause of diverse infections or chronic disease. This microbe has natural resistance to several kinds of antibiotics, because of the species’ outer membrane, efflux pumps and growth as a biofilm. This bacterium can acquire increased resistance with specific point mutations. Bacteriophage (phage), however, can lyse these bacteria. Therefore, in the present study, we assessed the host range of phages isolates and their ability to lyse antibiotic-resistant P. aeruginosa. Present phages could lyse many strains of P. aeruginosa (28/39), including strains with high resistance to fluoroquinolones (4/6). In conclusion, application of phages for antibiotic-resistant bacteria is greatly effective. To avoid pervasive antibiotic-resistant bacteria, further development of phage usage for disease treatment is required.