Pain in oxaliplatin-induced neuropathy - Sensitisation in the peripheral and central nociceptive system
Pain in oxaliplatin-induced neuropathy - Sensitisation in the peripheral and central nociceptive system
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DOI：
10.1016/j.ejca.2007.07.030
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发表时间：
2007-12-01
影响因子：
8.4
通讯作者：
Baron, Ralf
中科院分区：
文献类型：
--
作者：
Binder, Andreas;Stengel, Maike;Baron, Ralf
背景资料：本研究的目的是确定急性奥沙利铂引起的神经病变的患者的躯体感觉特征和疼痛类型，并与此相关的配置文件，据此检测到的潜在的病理生理mechanism.Patients和方法：16例奥沙利铂治疗癌症的特点与神经系统评估和一个标准化的和验证的一套定量感觉测试（QST）。患者被分配到两组，根据存在或不存在的疼痛症状的急性neuropathy.Results：与正常数据的比较显示，疼痛症状的患者的特征体感配置文件的冷和机械痛觉过敏。组间分析显示，额外的热痛觉过敏和温暖hypothesia.Conclusion：疼痛症状的急性奥沙利铂引起的神经病变相关的外周（冷和热痛觉过敏）和中枢神经伤害性系统（机械痛觉过敏）内的敏感化的迹象。这加强了抗惊厥药和抗抑郁药治疗的理论基础，并促进了对离子通道和受体相关机制的研究。(c)2007爱思唯尔有限公司保留所有权利。
Background: This study aimed to determine the somatosensory characteristics and pain types in patients with acute oxaliplatin-induced neuropathy and to relate this profile to the hereby detected underlying pathophysiological mechanisms.Patients and methods: Sixteen patients treated with oxaliplatin for cancer were characterised with neurological assessment and a standardised and validated set for quantitative sensory testing (QST). Patients were allocated to two groups depending on the presence or absence of pain symptoms of acute neuropathy.Results: Comparison with normative data revealed in patients with pain symptoms a characteristic somatosensory profile of cold and mechanical hyperalgesia. Group-to-group analysis revealed additional heat hyperalgesia and warm hypoesthesia.Conclusion: Pain symptoms of acute oxaliplatin-induced neuropathy are related to signs of sensitisation within the peripheral (cold and heat hyperalgesia) and central nervous nociceptive system (mechanical hyperalgesia). This strengthens the rationale for treatment with anticonvulsants and antidepressants and fosters research on ion channel and receptor related mechanisms. (c) 2007 Elsevier Ltd. All rights reserved.