MOLECULAR AND CRYSTAL-STRUCTURE OF STREPTONIGRIN
MOLECULAR AND CRYSTAL-STRUCTURE OF STREPTONIGRIN
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DOI：
10.1021/ja00842a033
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发表时间：
1975-01-01
影响因子：
15
通讯作者：
LIPSCOMB, WN
中科院分区：
文献类型：
--
作者：
CHIU, YYH;LIPSCOMB, WN
由Rao、Biemann和Woodward指定的化学结构在与乙酸乙酯共结晶的链霉素的x射线衍射研究中得到证实。环A、B和C，包括环C上的羧基，几乎是共面的。这种结构部分是由环C的NH2和环b中的N原子之间的短的，可能弯曲的氢键（2.65 Á）维持的。空间群是2\2\2，在一个尺寸为a= 13.676, b= 30.663和C = 6.821 Á的单元胞中有4个链黑素分子和4个乙酸乙酯分子。对于1677独立x射线衍射的最大值R=
The chemicalstructure assigned by Rao, Biemann, and Woodward is confirmed in an X-ray diffraction study of streptonigrin cocrystallized with ethyl acetate. Rings A, B, and C, including the carboxyl group on ring C, are very nearly coplanar. This configuration is partially maintainedby a short, probably bent, hydrogen bond (2.65 Á) between the NH2 of ring C and the N atom within ring B. The space group is 2\2\2, and there are four molecules of streptonigrin and four molecules of ethylacetate in a unit cell havingdimensions a= 13.676, b= 30.663, and c= 6.821 Á. For the 1677 independent X-ray diffraction maximathe value of R=