Benzodiazepine use and risk of dementia:: A nested case-control study
Benzodiazepine use and risk of dementia:: A nested case-control study
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DOI：
10.1016/s0895-4356(01)00453-x
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发表时间：
2002-03-01
影响因子：
7.2
通讯作者：
Moride, Y
中科院分区：
文献类型：
--
作者：
Lagnaoui, R;Bégaud, B;Moride, Y
这篇文章的目的是检查苯二氮卓类药物的使用和老年痴呆的风险之间可能的联系。这是一项在法国波尔多地区社区设置的巢式病例对照研究。参与者是1989年至1997年期间随访的3,777名老年人（65岁及以上）的代表性样本。主要的结局指标是痴呆病例与非痴呆对照中苯二氮卓类药物的使用。根据医学和心理学数据，根据《精神疾病诊断和统计手册》第三版的标准，诊断出150名患者患有痴呆症。苯二氮卓类药物的使用信息通过面对面访谈和由训练有素的神经心理学家对患者药箱进行视觉评估获得。在控制了年龄、性别、受教育程度、独居、饮酒、精神病史和抑郁症状后，曾使用苯二氮卓类药物与痴呆风险显著增加相关[校正优势比（OR）， 1.7 95%置信区间，1.2-2.4]。以前的使用与痴呆风险显著增加相关（调整OR）。2.3, 95% ci, 1.2-4.5)。未发现痴呆与当前苯二氮卓类药物的使用之间存在关联（校正OR为1.0；95% CI为0.6-1.6）。我们的发现表明，以前使用苯二氮卓类药物可能是痴呆的一个危险因素，但还需要更详细的调查。(C) 2002爱思唯尔科学有限公司版权所有。
The objective of this article was to examine the possible association between benzudiazepine use and the risk of dementia in the elderly. This was a nested case-control study set in community settings in Bordeaux area, France. The participants were a representative sample of 3,777 elderly persons (65 years of age and older) followed from 1989 to 1997. The main outcome measures were the use of benzodiazepines in incident cases of dementia versus nondemented controls. On the basis of medical and psychological data, 150 patients were diagnosed with dementia according to the criteria of the third revision of the Diagnostic and Statistical Manual of Mental Disorders. Information on benzodiazepine use was obtained by face-to-face interview and visual assessment of patient's medicine chest by a trained neuropsychologist. After controlling for age, gender, education level, living alone, wine consumption, psychiatric history, and depressive symptomatology, ever use of benzodiazepines, was associated with a significantly increased risk of dementia [adjusted odds ratio (OR), 1.7 95% confidence interval, 1.2-2.4]. Former use was associated with a significantly increased risk of dementia (adjusted OR. 2.3, 95% CI, 1.2-4.5). No association was found between dementia and the current use of benzodiazepines (adjusted OR, 1.0; 95% CI, 0.6-1.6). Our finding suggest that former use of benzodiazepines could be a risk factor for dementia, but more detailed investigation a-re needed. (C) 2002 Elsevier Science Inc. All rights reserved.