Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats
Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats
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DOI：
10.1097/01.ccm.0000182796.11329.3b
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发表时间：
2005-10-01
影响因子：
8.8
通讯作者：
Takeda, J
中科院分区：
文献类型：
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作者：
Suzuki, T;Morisaki, H;Takeda, J
目的：由于已知-受体阻滞剂治疗对心脏损伤（如梗死）的患者有效，我们设计了本研究，以检测输注β(1)选择性受体阻滞剂艾司洛尔对腹膜炎诱导的脓毒症大鼠心肌功能的保护作用。设计：随机动物研究。环境：大学研究实验室。实验对象：31只大鼠经盲肠结扎穿孔引起腹膜炎。干预措施：盲肠结扎穿孔后，将大鼠随机分为对照组（生理盐水2 mL/hr， n = 11）、低剂量艾司洛尔组（10 mg/kg/hr, n = 10）、高剂量艾司洛尔组（20 mg/kg/hr, n = 10）。在获得血液样本用于测量24小时动脉乳酸和肿瘤坏死因子- α后，我们在一个孤立的灌注心脏制备中评估了不同预负荷下的心输出量、心肌耗氧量和心脏效率（心输出量x峰值收缩压/心肌耗氧量）。测量和主要结果：与对照组相比，艾司洛尔输注没有引起动脉乳酸水平升高，但降低了肿瘤坏死因子- α浓度(p
Objective: Since beta-blocker therapy is known to be effective in patients with an injured heart, such as infarction, we designed the present study to examine the protective effects of infusion of the beta(1)-selective blocker esmolol on myocardial function in peritonitis-induced septic rats using an isolated working heart preparation.Design: Randomized animal study.Setting: University research laboratory.Subjects: Thirty-one rats treated with cecal ligation and perforation to evoke peritonitis.Interventions: After cecal ligation and perforation, rats were randomly allocated to the control group (normal saline 2 mL/hr, n = 11), low-dose esmolol group (10 mg/kg/hr, n = 10), or high-dose esmolol group (20 mg/kg/hr, n = 10). After obtaining blood samples for measurement of arterial lactate and tumor necrosis factor-alpha at 24 hrs, we assessed cardiac output, myocardial oxygen consumption, and cardiac efficiency (cardiac output x peak systolic pressure/myocardial oxygen consumption) at various preloads in an isolated perfused heart preparation.Measurements and Main Results: Esmolol infusion did not cause an elevation of arterial lactate levels but reduced tumor necrosis factor-alpha concentrations vs. the control group (p