The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007.
The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007.
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DOI：
10.1007/s10995-013-1234-9
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发表时间：
2014-01
影响因子：
2.3
通讯作者：
Li DK
中科院分区：
文献类型：
--
作者：
Avalos LA;Chen H;Yang C;Andrade SE;Cooper WO;Cheetham CT;Davis RL;Dublin S;Hammad TA;Kaplan S;Pawloski PA;Raebel MA;Scott PE;Smith DH;Toh S;Li DK
评价美国孕妇队列中妊娠期间暴露于抗病毒药物的患病率、趋势、时间和持续时间，并评价妊娠期间接受抗病毒药物治疗的女性中诊断为病毒感染的分娩比例。2001年至2007年期间，年龄在15至45岁之间的妇女的活产分娩被纳入妊娠期药物暴露风险评估计划（MEPREP），这是美国食品和药物管理局与11个健康计划之间的合作研究计划。评估了她们在妊娠期间暴露于抗病毒药物的患病率、时间、持续时间和时间趋势。我们还计算了暴露于抗病毒药物的患者中病毒感染诊断的分娩比例。在664，297例活产婴儿中，妊娠期间抗病毒暴露的总体患病率为4%（n= 25，155）。在2001年至2007年期间，怀孕期间抗病毒药物暴露增加了一倍，从2.5%增加到5%。最常用的抗病毒药物是阿昔洛韦，有3%的分娩接触，大多数接触发生在妊娠早期。大多数接触抗病毒药物的分娩时间少于30天（占所有活产的2%）。40%的孕妇在分娩时接触了抗病毒药物，她们被诊断出患有疱疹。我们的研究结果强调了随着时间的推移，分娩婴儿的妇女暴露于抗病毒药物的患病率增加。这些发现支持了大型，精心设计的研究，以评估这些药物在怀孕期间的安全性和有效性的必要性。
To evaluate the prevalence, trends, timing and duration of exposure to antiviral medications during pregnancy within a US cohort of pregnant women and to evaluate the proportion of deliveries with a viral infection diagnosis among women given antiviral medication during pregnancy. Live-born deliveries between 2001 and 2007, to women aged 15 to 45 years, were included from the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP), a collaborative research program between the U.S. Food and Drug Administration and eleven health plans. They were evaluated for prevalence, timing, duration, and temporal trends of exposure to antiviral medications during pregnancy. We also calculated the proportion of deliveries with a viral infection diagnosis among those exposed to antiviral medications. Among 664,297 live births, the overall prevalence of antiviral exposure during pregnancy was 4% (n=25,155). Between 2001 and 2007, antiviral medication exposure during pregnancy doubled from 2.5% to 5%. The most commonly used antiviral medication was acyclovir, with 3% of the deliveries being exposed and most of the exposure occurring after the 1st trimester. Most deliveries exposed to antiviral medications were exposed for less than 30 days (2% of all live births). Forty percent of the women delivering an infant exposed to antiviral medications had a herpes diagnosis. Our findings highlight the increased prevalence of women delivering an infant exposed to antiviral medications over time. These findings support the need for large, well-designed studies to assess the safety and effectiveness of these medications during pregnancy.
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DOI：
10.1002/bdra.20013
发表时间：
2004-04-01
影响因子：
--
作者：
Stone, KM;Reiff-Eldridge, R;Andrews, EB
通讯作者：
Andrews, EB
影响因子：
2.6
作者：
Raebel, MA;Ellis, JL;Andrade, SE
通讯作者：
Andrade, SE
DOI：
10.1016/s0272-0590(83)80105-5
发表时间：
1983-01-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
--
作者：
MOORE, HL;SZCZECH, GM;TUCKER, WE
通讯作者：
TUCKER, WE
影响因子：
120.7
作者：
Xu, Fujie;Sternberg, Maya R.;Markowitz, Lauri E.
通讯作者：
Markowitz, Lauri E.
影响因子：
2.3
作者：
Andrade, Susan E.;Davis, Robert L.;Scott, Pamela E.
通讯作者：
Scott, Pamela E.