A putative human papillomavirus type 57 new subtype isolated from plantar epidermoid cysts without intracytoplasmic inclusion bodies
A putative human papillomavirus type 57 new subtype isolated from plantar epidermoid cysts without intracytoplasmic inclusion bodies
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DOI：
10.1099/0022-1317-79-8-1977
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发表时间：
1998-08-01
影响因子：
3.8
通讯作者：
Kawai, S
中科院分区：
文献类型：
--
作者：
Kitasato, H;Egawa, K;Kawai, S
人乳头瘤病毒60型（HPV-60）是唯一的病毒类型，已确定在表皮样囊肿。在这项研究中，HPV-57 DNA被发现在18个足底表皮样囊肿与HPV-60相关的囊肿不同的组织学特征，使用PCR和Southern杂交。HPV-57相关囊肿具有类似HPV-2特异性细胞病变效应的特征。从2例患者中分离的2个HPV-57 DNA克隆的序列相同，但在某些位置与HPV-57 a和HPV-57 b的序列不同。这种假定的新亚型暂时命名为HPV-57 c，可能与足底表皮样囊肿有关，其组织学特征类似于HPV-2特异性细胞病变效应。
Human papillomavirus type 60 (HPV-60) is the only virus type that has been identified in epidermoid cysts. In this study, HPV-57 DNA was found in three out of 18 plantar epidermoid cysts with different histological features from HPV-60-associated cysts, using PCR and Southern hybridization. The HPV-57-associated cysts had features resembling an HPV-2-specific cytopathic effect. The sequences of two HPV-57 DNA clones isolated from two patients were identical, but differed at some positions from those of HPV-57a and HPV-57b. This putative new subtype was tentatively designated as HPV-57c, and may be associated with plantar epidermoid cysts showing histological features resembling the HPV-2-specific cytopathic effect.