Importance of Lymph Node Involvement in Pancreatic Neuroendocrine Tumors: Impact on Survival and Implications for Surgical Resection
Importance of Lymph Node Involvement in Pancreatic Neuroendocrine Tumors: Impact on Survival and Implications for Surgical Resection
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DOI：
10.1007/s11605-014-2624-z
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发表时间：
2015-01-01
影响因子：
3.2
通讯作者：
Wasif, Nabil
中科院分区：
文献类型：
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作者：
Curran, Thomas;Pockaj, Barbara A.;Wasif, Nabil
背景：关于胰腺神经内分泌肿瘤（PNETs）患者淋巴结转移的预测因素及其对生存的影响存在矛盾的数据。我们的目的是确定与淋巴结受累相关的因素，并评估淋巴结转移对生存的影响。方法纳入1988 - 2010年SEER肿瘤登记资料中所有因PNETs接受手术的患者。分别使用logistic回归和Cox回归评估淋巴结受累和疾病特异性生存（DSS）的预测因子。结果1915例患者接受了PNET手术（62%无功能）。淋巴结阳性与肿瘤大小增加有关(p
Background Conflicting data exist on predictors of nodal metastases and their impact on survival in patients with pancreatic neuroendocrine tumors (PNETs). We aim to identify factors associated with lymph node involvement and evaluate the effect of nodal metastases on survival.Methods All patients undergoing surgery for PNETs in the Surveillance, Epidemiology, and End Results (SEER) tumor registry from 1988 to 2010 were included. Predictors of lymph node involvement and disease-specific survival (DSS) were evaluated using logistic regression and Cox regression, respectively.Results Patients (1,915) underwent surgery for a PNET (62 % nonfunctional). Nodal positivity was associated with increasing tumor size (p