Extracellular gadolinium-based contrast media: An overview
Extracellular gadolinium-based contrast media: An overview
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DOI：
10.1016/j.ejrad.2008.01.023
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发表时间：
2008-05-01
影响因子：
3.3
通讯作者：
Van Der Molen, Aart J.
中科院分区：
文献类型：
--
作者：
Bellin, Marie-France;Van Der Molen, Aart J.
细胞外磁共振成像（MRI）造影剂的使用日益增加，静脉注射后它们会改变图像对比度；它们主要缩短组织的T1弛豫时间。这些变化的程度和位置提供了大量的诊断信息。然而，基于钆的造影剂（Gd - CA）并非惰性药物。它们可能导致急性非肾性不良反应（如类过敏反应）、急性肾性不良反应（如造影剂肾病）、迟发性不良反应（肾源性系统性纤维化）以及注射部位的问题（如局部坏死）。这篇综述描述了Gd - CA的现状、其作用机制、化学结构、药代动力学、剂量、排泄、肾毒性和不良事件。(C) 2008爱思唯尔爱尔兰有限公司。保留所有权利。
Increasing use is made of extracellular MRI contrast agents that alter the image contrast following intravenous administration; they predominantly shorten the T1 relaxation time of tissues. The degree and location of these changes provide substantial diagnostic information. However gadolinium-based contrast agents (Gd-CA) are not inert drugs. They may cause acute non-renal adverse reactions (e.g. anaphylactoid reactions), acute renal adverse reactions (e.g. contrast induced nephropathy), delayed adverse reactions (nephrogenic systemic fibrosis) and problems at the site of injection (e.g. local necrosis). This review describes the current status of Gd-CA, their mechanism of action, chemical structure, pharmacokinetics, dosage, elimination, nephrotoxicity and adverse events. (C) 2008 Elsevier Ireland Ltd. All rights reserved.