What Fuels Natural Killers? Metabolism and NK Cell Responses.
What Fuels Natural Killers? Metabolism and NK Cell Responses.
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DOI：
10.3389/fimmu.2017.00367
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发表时间：
2017
影响因子：
7.3
通讯作者：
Finlay DK
中科院分区：
文献类型：
--
作者：
Gardiner CM;Finlay DK
越来越多的人意识到细胞新陈代谢在决定淋巴细胞反应的过程中很重要。此外，在许多不同的疾病中，代谢过程的变化与淋巴细胞功能障碍有关。虽然早期对淋巴细胞功能的代谢调节的研究大多集中在T淋巴细胞上，但对代谢途径如何影响自然杀伤(NK)细胞反应的理解现在开始出现。在这篇综述文章中，我们将讨论细胞代谢如何影响淋巴细胞功能，尤其是NK细胞。
There is a growing appreciation that cellular metabolism is important in determining the course of lymphocyte responses. Additionally, changes in metabolic processes have been linked to dysfunctional lymphocyte functions in a number of different diseases. While most early studies of metabolic regulation of lymphocyte function focused on T lymphocytes, an understanding of how metabolic pathways impact upon natural killer (NK) cell responses is now starting to emerge. In this review article, we will discuss how cellular metabolism influences lymphocyte function with a particular focus upon NK cells.