Trends of Intra-Cranial Bacterial Infection in Patients Requiring Emergency Neurosurgery
Trends of Intra-Cranial Bacterial Infection in Patients Requiring Emergency Neurosurgery
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急诊神经外科患者颅内细菌感染的趋势
DOI：
10.1089/sur.2019.317
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发表时间：
2020
影响因子：
2
通讯作者：
Zhou Liangfu
中科院分区：
文献类型：
--
作者：
Yang Weijian;Wu Xing;Li Zhiqi;Yuan Qiang;Wu Gang;Yu Jian;Wu Xuehai;Du Zhuoying;Hu Jin;Zhou Liangfu
背景：颅内细菌感染是急诊神经外科患者的严重并发症，目前关于这些感染的趋势和抗菌药物耐药率的数据很少。方法：对2009年1月至2018年12月在我院急诊神经外科中心收治的颅内细菌感染患者进行回顾性调查。收集人口统计学特征、病原菌及药敏试验结果。结果：共纳入100例颅内细菌感染患者，占我院患者的1.41%。从脑脊液中培养出123株细菌，其中革兰氏阴性（GN）细菌96株，革兰氏阳性（GP）细菌27株。与GP细菌相比，接近研究结束时，GN细菌的比例增加到75.0%。与鲍曼不动杆菌相比，肺炎克雷伯菌也呈上升趋势。大多数细菌具有多重耐药（MDR）。我们进一步分析了同一患者CSF和痰培养的一致性。脑脊液中肺炎克雷伯菌和鲍曼不动杆菌的检出率分别为77.0%和62.0%。结论：从脑脊液中检出的细菌以GN为主。GN菌呈上升趋势，尤其是肺炎克雷伯菌。此外，大多数细菌是耐多药。
Background:Intra-cranial bacterial infection is a serious complication in emergency neurosurgical patients, and few data are available on the trends of these infections and the rates of antibacterial drug resistance.Methods:We surveyed retrospectively the patients with intra-cranial bacterial infection in our emergency neurosurgical center between January 2009 and December 2018. Demographic characteristics, causative bacteria, and antimicrobial susceptibility test results were collected.Results:A total of 100 patients with intra-cranial bacterial infection, 1.41% of our patients, were enrolled. There were 123 strains of bacteria cultured from the cerebrospinal fluid (CSF), consisting of 96 strains of gram-negative (GN) bacteria and 27 strains of gram-positive (GP) bacteria. Compared with the GP bacteria, the percentage of GN bacteria increased to 75.0% of the total near the end of the study. Compared withAcinetobacter baumannii,Klebsiella pneumoniaealso showed an uptrend. Most of the bacteria were multi–drug-resistant (MDR). We further analyzed the consistency of CSF and sputum cultures from the same patient. The ratio ofKlebsiella pneumoniaeandAcinetobacter baumanniito the corresponding strains in the CSF were 77.0% and 62.0%.Conclusions:The bacteria recovered from the CSF were mainly GN. The tendency of GN bacteria showed an uptrend, especially forKlebsiella pneumoniae. Furthermore, most of the bacteria were MDR.