Methadone and perinatal outcomes: a prospective cohort study
Methadone and perinatal outcomes: a prospective cohort study
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DOI：
10.1111/j.1360-0443.2012.03844.x
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发表时间：
2012-08-01
期刊：
影响因子：
6
通讯作者：
Murphy, Deirdre J.
中科院分区：
文献类型：
--
作者：
Cleary, Brian J.;Eogan, Maeve;Murphy, Deirdre J.
妊娠期使用美沙酮与不良围产期结局和新生儿戒断综合征（NAS）有关。本研究旨在检查围产期结局和NAS与（i）合并用药和（ii）美沙酮剂量的关系。设计前瞻性队列研究。两家三级妇产医院。2009年7月至2010年7月期间，共招募了117名接受美沙酮维持治疗的孕妇。使用成瘾严重程度指数记录伴随药物使用的信息。围产期结局包括早产（
Aims Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS). This study aimed to examine perinatal outcomes and NAS in relation to (i) concomitant drug use and (ii) methadone dose. Design Prospective cohort study. Setting Two tertiary care maternity hospitals. Participants A total of 117 pregnant women on methadone maintenance treatment recruited between July 2009 and July 2010. Measurements Information on concomitant drug use was recorded with the Addiction Severity Index. Perinatal outcomes included pre-term birth (