Increased Urinary Excretion of Iohexol after Enteral Administration in Patients with Ileal Crohn's Disease
Increased Urinary Excretion of Iohexol after Enteral Administration in Patients with Ileal Crohn's Disease
复制标题
回肠克罗恩病患者肠内给药后碘海醇尿排泄增加
DOI：
10.1177/028418519303400307
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发表时间：
1993
期刊：
影响因子：
1.3
通讯作者：
H. Lindén
中科院分区：
文献类型：
--
作者：
L. Halme;J. Edgren;K. V. von Smitten;H. Lindén
碘海醇是一种水溶性造影剂，部分通过小肠粘膜吸收/渗透，并在尿液中原封不动地排泄。对12例回肠克罗恩病患者和10例健康对照口服碘海醇，测定其在尿液中的排泄。所有患者均行双对比造影确定克隆氏病的位置和活动性，9例行回肠镜检查和活检。采用反相高效液相色谱法测定大鼠血清和24小时尿液中碘己醇浓度。活动期克罗恩病患者的尿碘己醇排泄量显著高于对照组。我们建议这种方法作为一种新的方法来测量克罗恩病的活动性和小肠粘膜的损伤。如果尿中排出的碘海醇超过口服摄入量的1%，肠炎和粘膜细胞损伤就是强烈的征兆。
Iohexol is a water-soluble contrast medium that is partly absorbed/permeated through mucosa of the small bowel and excreted unchanged in the urine. Iohexol was administered orally to 12 patients with Crohn's disease of the ileum and to 10 healthy controls to measure its excretion in the urine. The location and activity of Crohn's disease were determined by barium double-contrast radiography in all patients and by ileoscopy and biopsy in 9 patients. Iohexol concentrations in serum and 24-hour urine were measured using reversed phase high-performance liquid chromatography. Urinary excretion of iohexol was significantly greater in patients with active Crohn's disease than in controls. We suggest this method as a new way of measuring Crohn's disease activity and mucosal damage in the small bowel. Bowel inflammation and mucosal cell damage are strongly indicated if the iohexol excreted in the urine is over 1% of the oral intake.
51-乙二胺四乙酸铬试验：评估炎症性肠病的有用试验。
DOI：
--
发表时间：
1986
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
O'Morain,CA;Abelow,AC;Chervu,LR;Fleischner,GM;Das,KM
通讯作者：
Das,KM