BK virus-associated hemorrhagic cystitis in pediatric cancer patients receiving high-dose cyclophosphamide
BK virus-associated hemorrhagic cystitis in pediatric cancer patients receiving high-dose cyclophosphamide
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DOI：
10.1097/mph.0b013e3181461f6c
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发表时间：
2007-09-01
影响因子：
1.2
通讯作者：
Silverman, Craig L.
中科院分区：
文献类型：
--
作者：
Cheerva, Alexandra C.;Raj, Ashok;Silverman, Craig L.
出血性膀胱炎(HQ)是恶唑磷酸盐化疗的已知并发症。BK病毒(BKV)通常被发现与干细胞移植患者的血尿有关；然而，仅用环磷酰胺化疗后很少有报道。作者报告了3例非移植的儿童肿瘤患者合并HC的BK病毒尿症。3例BKV患者较1例BKV阴性HC患者血尿时间延长(14~16wk)(10wk)。HC需要延迟化疗，也需要延长支持性护理。1例患者静脉注射西多福韦，BK尿和血尿消失。BKV可能与接受大剂量恶唑磷化疗的非干细胞移植患者发生HC有关。在BK病毒尿症患者中，HC可能出现得较早且持续时间较长。细菌培养阴性的环磷酰胺或异环磷酰胺后出现HC的患者应进行BKV检查。西多福韦对某些BK病毒尿症和HC患者可能是有益的，然而，确定的数据将需要临床试验。
Hemorrhagic cystitis (HQ is a known complication of oxazophosphorine chemotherapy. BK virus (BKV) has been commonly found to be associated with hematuria in stem cell transplant patients; however, it has rarely been reported after cyclophosphamide chemotherapy alone. The authors present 3 cases of BK viruria with HC in nontransplant pediatric oncology patients. The 3 patients with BKV had more prolonged hematuria (14 to 16wk) compared with 1 patient with BKV-negative HC (10wk). The HC necessitated chemotherapy delays and also prolonged supportive care. One patient was treated with intravenous cidofovir with resolution of BK viruria and hematuria. BKV may have an association with the development of HC in nonstem cell transplant patients receiving high-dose oxazophosphorine chemotherapy. HC may present early and be more prolonged in patients with BK viruria. Patients with HC after cyclophosphamide or ifosfamide with negative bacterial cultures should be studied for BKV. Cidofovir may be beneficial in certain patients with BK viruria and HC however, definitive data will require a clinical trial.