Fluorous Linker Facilitated Synthesis of Teichoic Acid Fragments
Fluorous Linker Facilitated Synthesis of Teichoic Acid Fragments
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DOI：
10.1021/ol2033652
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发表时间：
2012-02-03
期刊：
影响因子：
5.2
通讯作者：
Van der Marel, Gijsbert A.
中科院分区：
文献类型：
--
作者：
Hogendorf, Wouter F. J.;Lameijer, Lucien N.;Van der Marel, Gijsbert A.
在一些具有生物相关性的（糖取代的）甘油磷壁酸片段的逐步溶液相合成中，对全氟辛基丙基磺酰乙醇作为一种新的磷酸酯保护基和氟相连接体的应用进行了评估。通过亚磷酰胺化学方法组装磷壁酸片段，直至十二聚体水平，使用相对少量过量的结构单元，并通过氟固相萃取（F - SPE）对受保护的中间体进行重复有效的纯化操作。
The use of perfluorooctylpropylsulfonylethanol as a new phosphate protecting group and fluorous linker is evaluated in the stepwise solution phase synthesis of a number of biologically relevant (carbohydrate substituted) glycerol teichoic acid fragments. Teichoic acid fragments, up to the dodecamer level, were assembled by means of phosphoramidite chemistry, using a relatively small excess of the building blocks and a repetitive efficient purification procedure of the protected intermediates by fluorous solid phase extraction (F-SPE).