Induction of serum Haemophilus influenzae type B capsular antibodies in adult volunteers fed cross-reacting Escherichia coli 075:K100:H5.
Induction of serum Haemophilus influenzae type B capsular antibodies in adult volunteers fed cross-reacting Escherichia coli 075:K100:H5.
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在喂食交叉反应大肠杆菌 075:K100:H5 的成年志愿者中诱导血清 B 型流感嗜血杆菌荚膜抗体。
DOI：
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发表时间：
1975
影响因子：
158.5
通讯作者：
J. Robbins
中科院分区：
文献类型：
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作者：
R. Schneerson;J. Robbins
通过喂食两种交叉反应大肠杆菌075：K100：H5菌株中的任何一种，在成年志愿者中诱导血清B型流感嗜血杆菌（HIT B）抗囊抗体。在所有进食的志愿者中，发生了持续长达8周的有限时期的定殖，没有偶然反应。14名正常志愿者中的9名和先前用6型流感嗜血杆菌多糖免疫的2名志愿者中的1名应答为血清6H型增加2倍以上。流感病毒抗体这些抗体由埃施诱导。大肠杆菌对该多糖具有特异性，并具有杀菌活性。本方法的安全性、在实验室动物中的可比结果以及其他埃施交叉反应菌株的鉴定。大肠杆菌与脑膜炎球菌和肺炎球菌荚膜多糖的关系表明，出生时这些非致病性生物体的定植可能提供了一种对包囊细菌引起的疾病进行预防性免疫的一般方法。
Serum Haemophilus influenzae Type b (HITB) anticapsular antibodies were induced in adult volunteers by feeding of either of two strains of a cross-reacting Escherichia coli 075:K100:H5. In all the fed volunteers colonization for a finite period lasting up to eight weeks occurred, without adventitious reactions. Nine of 14 normal volunteers and one of two volunteers previously immunized with the Type 6 H.influenzae polysaccharide responded with a greater than twofold increase in serum Type 6H. influenzae antibodies. These antibodies induced by Esch. coli were specific for the capsular polysaccharide and had bactericidal activity. The safety of this procedure, the comparable results in laboratory animals and the identification of other cross-reacting strains of Esch. coli with meningococcal and pneumococcal capsular polysaccharides suggest that colonization with these nonpathogenic organisms at birth may provide a general method of preventive immunization to diseases caused by encapsulated bacteria.