Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.
Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.
复制标题
腺病毒 E1A12S 产物的启动子特异性反式激活涉及单独的 E1A 结构域。
DOI：
10.1128/mcb.12.10.4391-4399.1992
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发表时间：
1992
影响因子：
5.3
通讯作者：
Nevins,JR
中科院分区：
文献类型：
--
作者：
Kraus,VB;Moran,E;Nevins,JR
Recent studies have shown that the adenovirus E1A12Sproduct cantrans-activate transcription by activating the transcription factor E2F. However, E2F cannot be the only target for the E1A12Sproduct, since several cellular promoters have been found to be activated by the E1A12Sprotein even though they lack E2F sites. Indeed, we now show that activation of thehsp70promoter by the E1A12Sproduct requires the TATAA sequence. Moreover, activation of thehsp70promoter requires the N-terminal domain of the E1A protein and does not require the conserved region 2 sequences which are required for the E2F-dependent activation of transcription. We conclude that the targeting of distinct transcription factors, leading totrans-activation of transcription of multiple promoters, involves distinct domains of the E1A proteins that are also required for oncogenic activity.
