Expression and clinical significance of glucose transporter-1 in pancreatic cancer
Expression and clinical significance of glucose transporter-1 in pancreatic cancer
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DOI：
10.3892/ol.2016.4586
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发表时间：
2016-07-01
期刊：
影响因子：
2.9
通讯作者：
Zhou, Jian
中科院分区：
文献类型：
--
作者：
Lu, Kai;Yang, Jian;Zhou, Jian
越来越多的证据表明，恶性细胞表现出葡萄糖摄取增加，这有利于缺氧环境中的生存和生长。葡萄糖转运蛋白-1 (GLUT-1) 在多种恶性肿瘤中过度表达。然而，迄今为止，尚未研究胰腺癌中GLUT-1表达与临床病理因素、F-180-氟脱氧葡萄糖摄取和肿瘤增殖之间的关联。本研究对53例胰腺癌组织中GLUT-1的表达进行了分析，发现GLUT-1在胰腺组织中过表达，与不良预后和临床病理特征相关，包括肿瘤大小增大、临床分期和淋巴结转移、最大标准化摄取值（SUVmax）和Ki-67表达。受试者工作特征曲线分析表明，SUVmax 截止值 4.830 与检测强阳性 GLUT-1 表达的最佳灵敏度 (88%) 和特异性 (71.4%) 相关。此外，由于发现GLUT-1的表达与Ki-67的表达相关，GLUT-1可能对胰腺癌的细胞增殖表现出显着的影响。总的来说，这些发现表明 GLUT-1 可能代表胰腺癌的预后指标和潜在的治疗靶点。
Increasing evidence has demonstrated that malignant cells exhibit increased glucose uptake, which facilitates survival and growth in a hypoxic environment. The glucose transporter-1 (GLUT-1) is overexpressed in a variety of malignant tumors. However, the association between GLUT-1 expression and clinicopathological factors, F-180-fluorodeoxy-glucose uptake and tumor proliferation in pancreatic cancer has not been investigated to date. In the present study, the expression of GLUT-1 in 53-pancreatic cancer tissues was analyzed, which revealed that GLUT- 1 was overexpressed in pancreatic tissue and correlated with poor prognosis and clinicopathological characteristics, including increased tumor size, clinical stage and lymph node metastasis, maximum standardized uptake value (SUVmax) and Ki-67 expression. The receiver operating characteristic curve analysis indicated that a cut-off SUVmax value of 4.830 was associated with optimal sensitivity (88%) and specificity (71.4%) for the detection of strong positive GLUT-1 expression. In addition, as the expression of GLUT-1 was found to correlate with Ki-67 expression, GLUT-1 may exhibit a significant effect on cell proliferation in pancreatic cancer. Overall, these findings indicate that GLUT-1 may represent a prognostic indicator, and a potential therapeutic target for pancreatic cancer.