Use of a biomimetic strategy to engineer bone
Use of a biomimetic strategy to engineer bone
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DOI：
10.1002/jbm.a.10453
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发表时间：
2003-06-15
影响因子：
4.9
通讯作者：
Shoichet, MS
中科院分区：
文献类型：
--
作者：
Holy, CE;Fialkov, JA;Shoichet, MS
在生物可降解聚合物支架中构建小梁状三维骨组织是一项重大挑战。使用一种新的处理技术，我们已经创建了一个可生物降解的支架与几何形状类似的骨小梁。当接种骨髓细胞，新的骨组织，其几何形状反映了该支架，是显而易见的整个支架体积和深度为10 mm。Prescent支架植入在非愈合兔节段性骨缺损允许新的功能性骨形成和骨愈合在8周内实现整个缺陷。这标志着第一个成功的三维骨组织工程修复报告使用自体骨髓细胞，而不使用补充生长因子。我们将我们的成功归功于新颖的支架形态。(C)2003 Wiley Periodicals，Inc.
Engineering trabecular-like, three-dimensional bone tissue throughout biodegradable polymer scaffolds is a significant challenge. Using a novel processing technique, we have created a biodegradable scaffold with geometry similar to that of trabecular bone. When seeded with bone-marrow cells, new bone tissue, the geometry of which reflected that of the scaffold, was evident throughout the scaffold volume and to a depth of 10 mm. Preseeded scaffolds implanted in non-healing rabbit segmental bone defects allowed new functional bone formation and bony union to be achieved throughout the defects within 8 weeks. This marks the first report of successful three-dimensional bone-tissue engineering repair using autologous marrow cells without the use of supplementary growth factors. We attribute our success to the novel scaffold morphology. (C) 2003 Wiley Periodicals, Inc.