Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles
Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles
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DOI：
10.3109/17435390.2011.604442
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发表时间：
2012-11-01
期刊：
影响因子：
5
通讯作者：
Ghandehari, Hamidreza
中科院分区：
文献类型：
--
作者：
Greish, Khaled;Thiagarajan, Giridhar;Ghandehari, Hamidreza
在免疫活性小鼠中，研究了聚酰胺胺树枝状聚合物和二氧化硅纳米颗粒（SNPs）的尺寸、表面电荷和表面官能度对其毒性的影响。在系统表征纳米颗粒后，将它们施用给CD-1（剖腹产衍生的-1）小鼠以评估急性毒性。一个明显的趋势，在纳米毒性的基础上，表面电荷和官能团，观察与树枝状聚合物，无论其大小。胺封端的树枝状聚合物在>10 mg/kg的剂量下是致命的，引起血液学并发症，如弥散性血管内凝血样表现，而类似大小的羧基和羟基封端的树枝状聚合物在50倍高的剂量下是耐受的。相比之下，较大的SNP比较小的SNP耐受性更差，无论其表面功能如何。这些发现对将这些纳米颗粒用于各种生物医学应用具有重要意义。
The influence of size, surface charge and surface functionality of poly(amido amine) dendrimers and silica nanoparticles (SNPs) on their toxicity was studied in immunocompetent mice. After systematic characterization of nanoparticles, they were administered to CD-1 (caesarean derived-1) mice to evaluate acute toxicity. A distinct trend in nanotoxicity based on surface charge and functional group was observed with dendrimers regardless of their size. Amine-terminated dendrimers were fatal at doses >10 mg/kg causing haematological complications such as disseminated intravascular coagulation-like manifestations whereas carboxyl-and hydroxyl-terminated dendrimers of similar sizes were tolerated at 50-fold higher doses. In contrast, larger SNPs were less tolerated than smaller SNPs irrespective of their surface functionality. These findings have important implications in the use of these nanoparticles for various biomedical applications.