Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
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DOI：
10.3791/54388
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发表时间：
2016-10-01
影响因子：
1.2
通讯作者：
Durand, Dominique M.
中科院分区：
文献类型：
--
作者：
Dweiri, Yazan M.;Stone, Matthew A.;Durand, Dominique M.
为了制造安全、坚固、可靠的神经假肢长期应用的多接触神经袖电极，已经进行了许多尝试。本方案描述了一种改进的圆柱形神经套电极的制造技术，以满足这些标准。最低限度的计算机辅助设计和制造（CAD和CAM）技能是必要的，以持续生产高精度（接触位置0.51 +/- 0.04 mm）和各种袖口尺寸的袖口。空间分布触点的精度和保留预先确定的几何形状的能力是优化袖带界面进行选择性记录和刺激的两个基本标准。本设计通过使用不同弹性的材料，使神经在纵向上的柔韧性最大化，同时在横向上保持足够的刚性，从而实现神经的重塑。在67毫米汞柱下，由于袖带内压力的增加，袖带的横截面积增加了25%。该测试显示了袖带的灵活性及其对植入后神经肿胀的反应。通过长期植入袖带（7.5个月）的触点阻抗和信噪比指标来检查触点接口的稳定性和记录质量，观察到分别为2.55 +/- 0.25 k ω和5.10 +/- 0.81 dB。
Many attempts have been made to manufacture multi-contact nerve cuff electrodes that are safe, robust and reliable for long term neuroprosthetic applications. This protocol describes a fabrication technique of a modified cylindrical nerve cuff electrode to meet these criteria. Minimum computer-aided design and manufacturing (CAD and CAM) skills are necessary to consistently produce cuffs with high precision (contact placement 0.51 +/- 0.04 mm) and various cuff sizes. The precision in spatially distributing the contacts and the ability to retain a predefined geometry accomplished with this design are two criteria essential to optimize the cuff's interface for selective recording and stimulation. The presented design also maximizes the flexibility in the longitudinal direction while maintaining sufficient rigidity in the transverse direction to reshape the nerve by using materials with different elasticities. The expansion of the cuff's cross sectional area as a result of increasing the pressure inside the cuff was observed to be 25% at 67 mm Hg. This test demonstrates the flexibility of the cuff and its response to nerve swelling post-implant. The stability of the contacts' interface and recording quality were also examined with contacts' impedance and signal-to-noise ratio metrics from a chronically implanted cuff (7.5 months), and observed to be 2.55 +/- 0.25 k Omega and 5.10 +/- 0.81 dB respectively.