Psychological Stress Expands Low Molecular Weight Iron Pool in Cerebral Cortex, Hippocampus, and Striatum of Rats
Psychological Stress Expands Low Molecular Weight Iron Pool in Cerebral Cortex, Hippocampus, and Striatum of Rats
复制标题
心理压力会扩大大鼠大脑皮层、海马和纹状体中的低分子量铁库
DOI：
10.1007/s12011-011-9230-7
复制
发表时间：
2012-04-01
影响因子：
3.9
通讯作者：
Li, Min
中科院分区：
文献类型：
--
作者：
Huang, Kai;Li, Hongxia;Li, Min
我们以前已经证明，心理应激（PS）可以导致铁积累在大脑皮层，海马和纹状体的大鼠。然而，为什么铁积累，并在什么氧化态铁积累在PS暴露大鼠的大脑还没有得到很好的阐明。在本研究中，我们研究了PS对大鼠脑内低分子量铁池（LMWIP）的影响。结果表明：（1）PS可使大鼠大脑皮层、海马和纹状体的LMWIP显著增加，（2）PS可使锥体细胞排列紊乱，锥体CA1和CA2神经元层数减少，（3）PS可使大鼠皮层和海马的铁蛋白（Fn）和肝啡肽（HP）的表达显著降低，（4）PS可使海马和皮层的LMWIP显著增加，（5）PS可使海马和皮层的LMWIP显著增加，（6）PS可使海马和皮层的LMWIP显著增加，（7）PS可使海马和皮层的LMWIP显著增加，（8）PS可使海马和皮层的LMWIP显著增加，（10）PS可使海马和皮层的LMWIP显著（4）PS可降低大鼠大脑皮层、海马和纹状体的超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽水平，升高丙二醛水平。结果表明，PS可显著增加LMWIP，这可能与PS诱导Fn、HP表达减少，导致铁储存和利用减少有关，而LMWIP的增加又可能导致氧化损伤加重。
We have previously demonstrated that psychological stress (PS) can cause iron to accumulate in the cerebral cortex, hippocampus, and striatum of rats. However, why iron accumulates and in what oxidation state iron it accumulates in the brain of PS-exposed rats has not been well elucidated. In the present study, we investigated the influence of PS on the low molecular weight iron pool (LMWIP) in the rat brain. The results showed that: (1) PS significantly expanded LMWIP in the cerebral cortex, hippocampus, and striatum in rats; (2) PS caused derangement of pyramidal cells and reduced the layers of pyramidal CA1 and CA2 neurons; (3) PS exposure greatly lowered the expression of ferritin (Fn) and hephaestin (HP) in the rat cortex and hippocampus; and (4) PS decreased superoxide dismutase, glutathione peroxidase, and glutathione level and increased malondialdehyde level in the cerebral cortex, hippocampus, and striatum in rats. These results indicated that PS could expand LMWIP significantly, which may be attributed to PS-induced decrease in Fn, HP expression, and the subsequent reduction in iron storage and utilization, and expansion of LMWIP could in turn lead to aggravation of oxidative damage.