Physical mapping of the albino-deletion complex in the mouse to localize alf/hsdr-1, a locus required for neonatal survival.
Physical mapping of the albino-deletion complex in the mouse to localize alf/hsdr-1, a locus required for neonatal survival.
复制标题
对小鼠白化缺失复合物进行物理定位，以定位 alf/hsdr-1（新生儿存活所需的基因座）。
DOI：
10.1016/s0888-7543(05)80217-4
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发表时间：
1992
期刊：
影响因子：
4.4
通讯作者：
Schütz,G
中科院分区：
文献类型：
--
作者：
Kelsey,G;Schedl,A;Ruppert,S;Niswander,L;Magnuson,T;Klebig,ML;Rinchik,EM;Schütz,G
The albino-deletion complex in the mouse defines a genetically well-characterized region of chromosome 7 in which a number of loci essential for normal development and viability reside. One locus, designatedalforhsdr-1, is necessary for neonatal survival. Its absence results in hypoglycemia associated with biochemical and ultrastructural abnormalities in hepatocytes and proximal tubule cells of the kidney. We constructed a long-range physical map of the region defined by the proximal segment of the albino-deletion complex as a step toward localizingalf/hsdr-1. Sixteen markers, including 11 whose isolation is described here and in the accompanying paper (A. Schedlet al., 1992,Genomics14, 288–297), were ordered on a panel of albino-deletion DNAs and their distribution was examined by pulsed-field gel electrophoresis. The resulting ≈4300-kb physical map covers the entire region absent from the prototypicalf/hsdr-1deletionC14CoS, estimated as ≈3600 kb. Since the deletionc11DSDcomplements and overlaps most ofc14CoS, alf/hsdr-1was mapped at the proximal extreme ofc14CoS, ≈3000 kb from the albino locus. The density of CpG islands was found to be very heterogeneous across the region mapped.
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影响因子：
9.8
作者：
Daniel Phaneuf;Yves Labelle;D. Bérubé;Karen C. Arden;Webster Cavenee;Richard Gagné;Robert M. Tanguay
通讯作者：
Daniel Phaneuf;Yves Labelle;D. Bérubé;Karen C. Arden;Webster Cavenee;Richard Gagné;Robert M. Tanguay
白化基因座周围染色体缺失的纯合小鼠中金属硫蛋白 mRNA 的表达。
DOI：
10.1073/pnas.85.4.1161
发表时间：
1988
影响因子：
11.1
作者：
DeFranco,D;MorrisJr,SM;Leonard,CM;Gluecksohn-Waelsch,S
通讯作者：
Gluecksohn-Waelsch,S
影响因子：
--
作者：
G. Pfeifer;A. Riggs
通讯作者：
G. Pfeifer;A. Riggs
通过高效诱变对小鼠 7 号染色体 6 至 11 厘摩区域进行精细结构功能分析的策略。
DOI：
--
发表时间：
1990
影响因子：
11.1
作者：
E. Rinchik;Donald A. Carpenter;P. Selby
通讯作者：
P. Selby
肝脏 NAD(P)H:氧化还原酶基因转录和 mRNA 水平显着增加与小鼠 7 号染色体缺失相关。
DOI：
10.1073/pnas.86.17.6699
发表时间：
1989
影响因子：
11.1
作者：
Daniel D. Petersen;Frank J. Gonzalez;Vesna Rapic;Christine A. Kozak;Jong;John E. Jones;D. Nebert
通讯作者：
D. Nebert