Azidothymidine-induced hyperpigmentation of skin and nails.
Azidothymidine-induced hyperpigmentation of skin and nails.
复制标题
叠氮胸苷诱导的皮肤和指甲色素沉着过度。
DOI：
10.1001/archderm.1989.01670210123028
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发表时间：
1989
影响因子：
--
通讯作者：
G. Steigleder
中科院分区：
文献类型：
--
作者：
C. Bendick;H. Rasokat;G. Steigleder
致编辑在治疗获得性免疫缺陷综合征（艾滋病）和艾滋病相关综合征患者时，叠氮胸苷（齐多夫定，Retrovir）发挥着重要作用：它是目前唯一具有临床证明的抗逆转录病毒活性的药物。它在世界范围内大规模使用。迄今为止，报道的大多数副作用是指叠氮胸苷的骨髓毒性，1只有少数报道涉及皮肤及其附件的不良反应。最近，Azon-Masoliver等人2在档案中报告了他们对两名白色患者在开始叠氮胸苷治疗后4个月和6个月的指甲上出现纵向条纹的观察结果。Panwalker 3以及Furth和Kazakis 4描述了他们在开始叠氮胸苷治疗后2周至6个月在黑人个体中观察到的涉及手指甲和脚趾甲的整个甲板的蓝色变色。在这里，我们描述的发展
To the Editor.— In the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex, azidothymidine (zidovudine, Retrovir) plays a significant role: it is the only medication with clinically proven antiretroviral activity currently available. It is used on a large scale worldwide. Most side effects reported so far refer to the myelotoxicity of azidothymidine,1there are only a few reports on adverse experiences involving the skin and its adnexes. Recently, Azon-Masoliver et al2reported in theArchiveson their observation of longitudinal streaks appearing on the fingernails of two white patients 4 and 6 months after the start of therapy with azidothymidine. Panwalker3as well as Furth and Kazakis4described a bluish discoloration involving the entire nail plate of both fingernails and toenails that they observed in black individuals 2 weeks to 6 months after the start of azidothymidine treatment. Herein we describe the development of