Associations between migraine attacks and nightly sleep characteristics among adults with episodic migraine: a prospective cohort study.
Associations between migraine attacks and nightly sleep characteristics among adults with episodic migraine: a prospective cohort study.
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DOI：
10.1093/sleep/zsaa001
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发表时间：
2020-01
期刊：
影响因子：
5.6
通讯作者：
A. Vgontzas;Wenyuan Li;Elizabeth Mostofsky;M. Rueschman;M. Mittleman;S. Bertisch
中科院分区：
文献类型：
--
作者：
A. Vgontzas;Wenyuan Li;Elizabeth Mostofsky;M. Rueschman;M. Mittleman;S. Bertisch
研究目标 鉴于偏头痛对夜间睡眠的直接影响尚不清楚，我们在 98 名患有阵发性偏头痛的成年人中前瞻性地研究了偏头痛是否与随后的睡眠持续时间较短、碎片化程度较高和质量较差有关。方法 参与者每天完成两次电子日记，并连续佩戴活动记录仪 6 周。我们使用调整后的多变量线性混合模型和特定受试者的截距，检查了与非头痛日相比，头痛日是否与当晚睡眠特征的变化相关。结果 参与者年龄为 35 ± 12 岁，其中 88% 为女性，平均每月发生 5 次偏头痛。在 4406 天的时间里，我们观察到了 1077 个头痛日，代表 823 个离散头痛。平均夜间客观睡眠时间为 7.3 ± 1.2 小时，效率为 89.5 ± 3.3%，入睡后醒来 (WASO) 44.8 ± 17.0 分钟。与无头痛当天晚上相比，头痛当天晚上的客观睡眠时间延长 7.3 分钟（95% CI：1.5，13.0）。与无头痛日相比，头痛日的客观睡眠效率、WASO 和报告的睡眠质量没有显着差异（睡眠效率：-0.06 分钟）。 结论 偏头痛后立即睡眠与发作性偏头痛患者睡眠持续时间较短、睡眠中断程度较高或睡眠质量较差无关。这些结果表明，对发作性偏头痛患者睡眠障碍的临床评估应独立于其偏头痛状态。
STUDY OBJECTIVES Given the unknown immediate impact of migraine on nighttime sleep, we prospectively examined whether migraine headaches were associated with subsequent shorter sleep duration, higher fragmentation and poorer quality in a cohort of 98 adults with episodic migraine. METHODS Participants completed twice-daily electronic diaries and wore actigraphs continuously for 6 weeks. We examined whether days with headaches were associated with changes in that night's sleep characteristics compared to non-headache days, using adjusted multivariable linear mixed models with subject-specific intercepts. RESULTS Participants were 35 ± 12 years old, 88% women, with an average of five migraine headaches/month. Over 4406 days, we observed 1077 headache days, representing 823 discrete headaches. Average nightly objective sleep duration was 7.3 ± 1.2 hours, efficiency 89.5 ± 3.3% and wake after sleep onset (WASO) 44.8 ± 17.0 minutes. Objective sleep duration was 7.3 minutes (95% CI:1.5, 13.0) longer on nights following a headache day compared to nights on a headache-free day. Objective sleep efficiency, WASO, and reported sleep quality were not significantly different on headache days compared to headache-free days (sleep efficiency: -0.06 min. CONCLUSIONS Sleep periods immediately following migraine headaches are not associated with shorter sleep duration, higher sleep disruption, or poorer sleep quality in patients with episodic migraine. These results suggest that clinical evaluation of sleep disturbance in patients with episodic migraine should be approached independently of their migraine status.