Synthesis and pharmacological evaluation of childinin E and several derivatives as anti-hyphal formation inhibitors against Candida albicans
Synthesis and pharmacological evaluation of childinin E and several derivatives as anti-hyphal formation inhibitors against Candida albicans
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DOI：
10.1016/j.tetlet.2020.152588
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发表时间：
2020-12-03
影响因子：
1.8
通讯作者：
Sugita, Yoshiaki
中科院分区：
文献类型：
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作者：
Kamauchi, Hitoshi;Hirata, Momoka;Sugita, Yoshiaki
天然高度取代的二苯甲酮 Childinin E (1) 先前是从真菌 Daldinia childiae 中分离出来的。在这里，我们描述了使用线性七步序列的 childinin E 和几种衍生物的全合成。通过抗菌丝形成试验评估了合成化合物对白色念珠菌的抗真菌特性。 Childnin E 和两种衍生物表现出抗菌丝形成活性。 (C) 2020 Elsevier Ltd. 保留所有权利。
The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using a linear seven-step sequence. The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti-hyphal formation test. Childnin E and two derivatives exhibited anti-hyphal formation activity. (C) 2020 Elsevier Ltd. All rights reserved.