Metabolic regulation of gene expression through histone acylations.
Metabolic regulation of gene expression through histone acylations.
复制标题
DOI：
10.1038/nrm.2016.140
复制
发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Sabari BR;Zhang D;Allis CD;Zhao Y
最近在组蛋白上鉴定了8种类型的短链赖氨酸（Lys）酰化：丙酰化、丁酰化、2-羟基异丁酰化、琥珀酰化、丙二酰化、戊二酰化、巴豆酰化和β-羟基丁酰化。新出现的证据表明，这些组蛋白修饰影响基因表达，并且在结构和功能上不同于广泛研究的组蛋白赖氨酸乙酰化。在这篇综述中，我们讨论了非乙酰基组蛋白酰化的酶和代谢机制的调节，酰化“读者”蛋白介导的不同酰化的影响，和他们的生理功能，包括在信号依赖的基因激活，精子发生，组织损伤和代谢诱导的压力。我们提出了一个模型来解释我们目前的理解，如何差异组蛋白酰化调节代谢的不同的酰基辅酶A的形式，这反过来又调节基因表达的调控。
Eight types of short-chain lysine (Lys) acylations have recently been identified on histones: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. Emerging evidence suggest that these histone modifications affect gene expression and are structurally and functionally different from the widely studied histone Lys acetylation. In this review, we discuss the regulation of non-acetyl histone acylation by enzymatic and metabolic mechanisms, acylation “reader” proteins that mediate the effects of different acylations, and their physiological functions, including in signal-dependent gene activation, spermatogenesis, tissue injury and metabolic-induced stress. We propose a model to explain our present understanding of how differential histone acylation is regulated by metabolism of the different acyl-CoA forms, which in turn modulate the regulation of gene expression.