Application of silicon-based cross-coupling technology to triflates.
Application of silicon-based cross-coupling technology to triflates.
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DOI：
10.1021/jo034809g
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发表时间：
2003-09
期刊：
影响因子：
--
通讯作者：
Shaundra Riggleman;P. DeShong
中科院分区：
文献类型：
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作者：
Shaundra Riggleman;P. DeShong
芳基杂氮硅三环与芳基三氟甲磺酸酯进行氟化物诱导的交叉偶联，以良好至优异的产率提供不对称联芳基衍生物。杂氮硅三环也与芳基碘和溴偶联，尽管加合物的产率低于相应的硅氧烷衍生物。使用丹麦的改进，芳基硅氧烷（其先前未能与三氟甲磺酸酯偶联）可用于三氟甲磺酸酯偶联，尽管产率低于相应的杂氮硅三环反应。
Aryl silatranes undergo fluoride-induced cross-coupling with aryl triflates to provide unsymmetrical biaryl derivatives in good to excellent yields. Silatranes also couple with aryl iodides and bromides, although the yields of adduct are lower than with the corresponding siloxane derivates. Aryl siloxanes (which had previously failed to couple with triflates) can be employed for triflate couplings using the Denmark modification, although the yields are lower than the corresponding silatrane reactions.