Functional neuroimaging of belief, disbelief, and uncertainty
Functional neuroimaging of belief, disbelief, and uncertainty
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DOI：
10.1002/ana.21301
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发表时间：
2008-02-01
影响因子：
11.2
通讯作者：
Cohen, Mark S.
中科院分区：
文献类型：
--
作者：
Harris, Sam;Sheth, Sameer A.;Cohen, Mark S.
目的：相信和不相信一个命题之间的差异是人类行为和情感最有效的调节器之一。当一个人接受一个陈述为真时，它就成为进一步思考和行动的基础;当它被拒绝为假时，它仍然是一串单词。本研究的目的是区分信念，不相信，和不确定性在brain.Methods水平：我们使用功能磁共振成像（fMRI）研究14名成年人的大脑，而他们判断书面陈述是“真”（信念），“假”（不相信），或“不可判定”（不确定性）。为了以独立于内容的方式描述信念、怀疑和不确定性，我们纳入了来自广泛类别的陈述：自传体的、数学的、地理的、宗教的、伦理的、语义的和事实的。结果：信念、怀疑和不确定性的状态不同地激活了前额叶和顶叶皮质的不同区域，以及基底神经节。解释：相信和不相信与不确定性的不同之处在于，两者都提供了可以随后告知行为和情绪的信息。这种差异的机制似乎涉及前扣带皮层和尾状核。虽然许多高级认知领域可能参与评估语言命题的真值，但最终接受一个陈述为“真”或拒绝它为“假”似乎依赖于内侧前额叶皮层和前额叶皮层中更原始的享乐处理。真理可能是美，而美不仅仅是隐喻意义上的真理，而虚假的命题可能实际上让我们厌恶。
Objective: The difference between believing and disbelieving a proposition is one of the most potent regulators of human behavior and emotion. When one accepts a statement as true, it becomes the basis for further thought and action; rejected as false, it remains a string of words. The purpose of this study was to differentiate belief, disbelief, and uncertainty at the level of the brain.Methods: We used functional magnetic resonance imaging (fMRI) to study the brains of 14 adults while they judged written statements to be "true" (belief), "false" (disbelief), or "undecidable" (uncertainty). To characterize belief, disbelief, and uncertainty in a content-independent manner, we included statements from a wide range of categories: autobiographical, mathematical, geographical, religious, ethical, semantic, and factual.Results: The states of belief, disbelief, and uncertainty differentially activated distinct regions of the prefrontal and parietal cortices, as well as the basal ganglia.Interpretation: Belief and disbelief differ from uncertainty in that both provide information that can subsequently inform behavior and emotion. The mechanism underlying this difference appears to involve the anterior cingulate cortex and the caudate. Although many areas of higher cognition are likely involved in assessing the truth-value of linguistic propositions, the final acceptance of a statement as "true" or its rejection as "false" appears to rely on more primitive, hedonic processing in the medial prefrontal cortex and the anterior insula. Truth may be beauty, and beauty truth, in more than a metaphorical sense, and false propositions may actually disgust us.