ABNORMAL THYROID-FUNCTION TEST-RESULTS IN PATIENTS WITH FISHER-EVANS SYNDROME
ABNORMAL THYROID-FUNCTION TEST-RESULTS IN PATIENTS WITH FISHER-EVANS SYNDROME
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DOI：
10.1007/bf03344937
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发表时间：
1993-03-01
影响因子：
5.4
通讯作者：
DARMIENTO, M
中科院分区：
文献类型：
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作者：
LIO, S;ALBIN, M;DARMIENTO, M
对费舍尔-埃文斯综合征 (FES) 患者的甲状腺功能进行了评估，并与仅受自身免疫性溶血性贫血 (AIHA) 影响的患者和仅受特发性血小板减少性紫癜 (ITP) 影响的患者进行比较。研究人群包括 20 名 FES 患者、44 名 AIHA 患者和 20 名 ITP 患者。所有患者均接受甲状腺功能异常和甲状腺自身抗体检查。分别有 40%、25% 和 10% 的患者甲状腺功能检测结果异常。 FES 中抗甲状腺抗体 (ATA) 的患病率为 25%；这高于仅受 AIHA 影响的患者 (11.4%) 或仅受 ITP (无) 影响的患者中 ATA 患病率的总和。受 FES 影响的患者分别有 20% 和 10% 存在亚临床原发性甲状腺功能减退症和高甲状腺素血症伴或不伴高三碘甲状腺原氨酸血症，血清 TSH 水平低于正常。属于前者。 75% 的 ATA 呈阳性。这些结果： i) 证实受 AIHA、ITP 和 FES 影响的患者中甲状腺检测结果异常的发生率很高； ii) 证明 FES 中自身免疫性甲状腺功能减退症的患病率较高； iii) 导致将 FES 作为多种自身免疫综合征之一的可能性。
Thyroid function was evaluated in patients affected by Fisher-Evans syndrome (FES) and compared to that of patients affected only by autoimmune hemolytic anemia (AIHA) and to that of patients affected only by idiopathic thrombocytopenic purpura (ITP). The study population consisted of 20 patients with FES, 44 with AIHA and 20 with ITP. All patients were examined for thyroid function abnormalities and thyroid autoantibodies. Abnormal thyroid function test results were observed in 40, 25 and 10% of the patients, respectively. The prevalence of antithyroid antibodies (ATA) in FES was 25%; this is higher than the sum of the prevalences of ATA in patients affected only by AIHA (11.4%) or only by ITP (none). Subclinical primary hypothyroidism and hyperthyroxinemia with or without hypertriiodothyroninemia, with TSH serum levels below normal, were present in 20% and 10% of patients affected by FES, respectively. Of the former. 75% were positive for ATA. These results: i) confirm the high prevalence of abnormal thyroid test results in patients affected by AIHA, ITP and FES; ii) demonstrate the higher prevalence of autoimmune hypothyroidism in FES; iii) lead to the possibility of including FES as one of the multiple autoimmune syndromes.