Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy.
Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy.
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DOI：
10.1364/oe.18.025973
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发表时间：
2010-12-06
期刊：
影响因子：
3.8
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Tian F;Delgado MR;Dhamne SC;Khan B;Alexandrakis G;Romero MI;Smith L;Reid D;Clegg NJ;Liu H
脑瘫是儿童最常见的运动障碍。目前可用的神经成像技术需要完全的身体限制和稳定性，因此对于儿科患者来说极其困难。在这里，我们报告的使用和量化的功能近红外光谱（fNIRS），以调查偏瘫CP儿童的感觉运动皮层的功能重组。16名先天性轻偏瘫儿童中有10名在手指敲击任务中进行了测量，并与16名年龄匹配的健康儿童中的8名进行了比较，总体测量成功率为60%。时空分析被用来量化运动激活和大脑偏侧化。这种定量方法揭示了7岁或7岁以上的健康儿童中一致的对侧运动激活。与此形成鲜明对比的是，先天性轻偏瘫的儿童表现出对侧、双侧和同侧运动激活的所有三种，这取决于儿科受试者的特定年龄。这项研究清楚地表明了fNIRS用于研究CP或其他皮质疾病儿童的皮质重组的可行性。
Cerebral palsy (CP) is the most common motor disorder in children. Currently available neuroimaging techniques require complete body confinement and steadiness and thus are extremely difficult for pediatric patients. Here, we report the use and quantification of functional near infrared spectroscopy (fNIRS) to investigate the functional reorganization of the sensorimotor cortex in children with hemiparetic CP. Ten of sixteen children with congenital hemiparesis were measured during finger tapping tasks and compared with eight of sixteen age-matched healthy children, with an overall measurement success rate of 60%. Spatiotemporal analysis was introduced to quantify the motor activation and brain laterality. Such a quantitative approach reveals a consistent, contralateral motor activation in healthy children at 7 years of age or older. In sharp contrast, children with congenital hemiparesis exhibit all three of contralateral, bilateral and ipsilateral motor activations, depending on specific ages of the pediatric subjects. This study clearly demonstrates the feasibility of fNIRS to be utilized for investigating cortical reorganization in children with CP or other cortical disorders.