Interval timing and midfrontal delta oscillations are impaired in Parkinson's disease patients with freezing of gait
Interval timing and midfrontal delta oscillations are impaired in Parkinson's disease patients with freezing of gait
复制标题
步态冻结的帕金森病患者的间期计时和额叶中段三角洲振荡受损
DOI：
10.1007/s00415-021-10843-9
复制
发表时间：
2021-10-21
影响因子：
6
通讯作者：
Singh, Arun
中科院分区：
文献类型：
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作者：
Bosch, Taylor J.;Barsainya, Richa;Singh, Arun
步态异常和认知功能障碍在帕金森病（PD）患者中很常见，并随着疾病进展而恶化。最近的证据表明，PD患者的步态异常和认知功能障碍之间存在密切关系，认知控制受损可能是步态异常的原因之一。然而，PD患者步态问题的认知功能障碍的病理生理机制尚不清楚。在这里，我们收集头皮脑电图（EEG）信号在7秒的时间间隔任务，以调查认知功能障碍的皮质机制在PD患者（PDFOG +，n = 34）和没有（PDFOG-，n = 37）冻结的步态，以及对照组（n = 37）。结果表明，PDFOG +组表现出最低的最大响应密度在7秒左右相比，PDFOG-和对照组，和这个响应密度峰值与步态异常FOG分数测量。EEG数据表明，PDFOG +在目标提示开始时减少了中额三角带功率，这也与最大反应密度和FOG评分相关。此外，我们的分类器在区分PDFOG +与PDFOG-和对照时表现得更好，当选择额中三角洲功率作为特征时，曲线下面积为0.93。这些研究结果表明，异常中额叶活动PDFOG +与认知功能障碍，并描述了认知和步态功能之间的机制关系PDFOG +。总的来说，这些结果可以促进PDFOG +的新型生物特征和脑刺激方法的发展。
Gait abnormalities and cognitive dysfunction are common in patients with Parkinson's disease (PD) and get worse with disease progression. Recent evidence has suggested a strong relationship between gait abnormalities and cognitive dysfunction in PD patients and impaired cognitive control could be one of the causes for abnormal gait patterns. However, the pathophysiological mechanisms of cognitive dysfunction in PD patients with gait problems are unclear. Here, we collected scalp electroencephalography (EEG) signals during a 7-s interval timing task to investigate the cortical mechanisms of cognitive dysfunction in PD patients with (PDFOG +, n = 34) and without (PDFOG-, n = 37) freezing of gait, as well as control subjects (n = 37). Results showed that the PDFOG + group exhibited the lowest maximum response density at around 7 s compared to PDFOG- and control groups, and this response density peak correlated with gait abnormalities as measured by FOG scores. EEG data demonstrated that PDFOG + had decreased midfrontal delta-band power at the onset of the target cue, which was also correlated with maximum response density and FOG scores. In addition, our classifier performed better at discriminating PDFOG + from PDFOG- and controls with an area under the curve of 0.93 when midfrontal delta power was chosen as a feature. These findings suggest that abnormal midfrontal activity in PDFOG + is related to cognitive dysfunction and describe the mechanistic relationship between cognitive and gait functions in PDFOG + . Overall, these results could advance the development of novel biosignatures and brain stimulation approaches for PDFOG + .