Behavioral state modulation of auditory activity in a vocal motor system
Behavioral state modulation of auditory activity in a vocal motor system
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DOI：
10.1126/science.282.5397.2250
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发表时间：
1998-12-18
期刊：
影响因子：
56.9
通讯作者：
Margoliash, D
中科院分区：
文献类型：
--
作者：
Dave, AS;Yu, AC;Margoliash, D
在清醒状态下，斑胸草雀的歌唱运动控制核（RA）的听觉反应远弱于麻醉状态。值得注意的是，睡眠诱导了正在进行的活动中复杂的爆发模式，并揭示了RA神经元强烈的听觉反应。局部注射去甲肾上腺素表明，反应强度的变化是通过感觉运动核HVc的神经调节控制发生的，该神经调节控制投射到RA，因此，运动获得听觉反馈，这是斑马雀学习和维持歌曲所需的，可能是通过神经调节来调节的。在睡眠期间，下行运动系统可能获得以爆发活动模式为代表的感觉运动歌曲记忆。
Neurons of the song motor control nucleus robustus archistriatalis (RA) exhibited far weaker auditory responses in awake than in anesthetized zebra finches, Remarkably, sleep induced complex patterns of bursts in ongoing activity and uncovered vigorous auditory responses of RA neurons. Local injections of norepinephrine suggested that the changes in response strength occur through neuromodulatory control of the sensorimotor nucleus HVc, which projects to RA, Thus, motor access to auditory feedback, which zebra finches require for song Learning and maintenance, may be regulated through neuromodulation, During sleep, the descending motor system may gain access to sensorimotor song memories represented as bursting patterns of activity.