Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway.
Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway.
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DOI：
10.1016/j.neuron.2005.05.026
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发表时间：
2005-07-07
期刊：
影响因子：
16.2
通讯作者：
Wilson SW
中科院分区：
文献类型：
--
作者：
Cavodeassi F;Carreira-Barbosa F;Young RM;Concha ML;Allende ML;Houart C;Tada M;Wilson SW
在前神经板的区域构图过程中，指定中间位置的细胞区域以采用视网膜身份。这些眼场细胞在经历不同于其他预期前脑区的形态发生事件时保持连贯。我们发现，Wnt信号通路的两个分支协调了细胞命运的决定和眼场形成过程中的细胞行为。Wnt/β-catenin信号通过Wnt8b和Fz8a的活性拮抗眼睛的特性。相反，Wnt11和Fz5至少部分地通过局部拮抗Wnt/β-连环蛋白信号来促进眼场发育。此外，Wnt11调节眼场细胞的行为，促进它们的凝聚力。综上所述，这些结果使我们能够假设一个模型，在该模型中，Wnt11和Fz5信号通过协调拮抗抑制视网膜识别和促进眼野细胞一致性的信号来促进眼睛的早期发育。
During regional patterning of the anterior neural plate, a medially positioned domain of cells is specified to adopt retinal identity. These eye field cells remain coherent as they undergo morphogenetic events distinct from other prospective forebrain domains. We show that two branches of the Wnt signaling pathway coordinate cell fate determination with cell behavior during eye field formation. Wnt/β-catenin signaling antagonizes eye specification through the activity of Wnt8b and Fz8a. In contrast, Wnt11 and Fz5 promote eye field development, at least in part, through local antagonism of Wnt/β-catenin signaling. Additionally, Wnt11 regulates the behavior of eye field cells, promoting their cohesion. Together, these results allow us to postulate a model in which Wnt11 and Fz5 signaling promotes early eye development through the coordinated antagonism of signals that suppress retinal identity and promotion of coherence of eye field cells.
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