Limited relapse in Guillain-Barré syndrome after plasma exchange.
Limited relapse in Guillain-Barré syndrome after plasma exchange.
复制标题
血浆置换后吉兰-巴利综合征的有限复发。
DOI：
10.1001/archneur.1988.00520270096026
复制
发表时间：
1988
影响因子：
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通讯作者：
Rita Addison
中科院分区：
文献类型：
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作者：
A. Ropper;James W. Albers;Rita Addison
94例连续急性格林-巴利综合征患者中有10例接受血浆置换治疗，在最初改善后复发。恶化发生在第一系列血浆交换后5至42天，通常是轻度的，在8名重新治疗的患者中，对第二系列血浆交换有反应。无慢性炎性脱髓鞘性多发性神经病。最初的交流开始于发病后3至22天（平均11天），结束于14至27天（平均19天）。这些有限复发患者的双相过程表明，血浆置换可清除一种循环因子，如果过早停止治疗，这种循环因子仍将保持活性。第二次，有时是第三次血浆置换的再治疗可能有效。
Ten of 94 consecutive patients with acute Guillain-Barré syndrome treated with plasma exchange relapsed after initial improvement. Deterioration occurred five to 42 days after the first series of exchanges, was usually mild, and in eight re-treated patients, responded to a second series of plasma exchanges. None developed chronic inflammatory demyelinating polyneuropathy. The initial exchanges began three to 22 days (mean, 11 days and ended 14 to 27 days (mean, 19 days after the onset of illness. The biphasic course on these patients with limited relapses suggests that plasma exchange removes a circulating factor that continues to be active if treatment is stopped too early. Re-treatment with a second, and sometimes a third, series of plasma exchanges may be affective.