Mossy fiber reorganization in the epileptic hippocampus
Mossy fiber reorganization in the epileptic hippocampus
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DOI：
10.1097/00019052-199704000-00006
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发表时间：
1997-04-01
影响因子：
4.8
通讯作者：
Lowenstein, DH
中科院分区：
文献类型：
--
作者：
Parent, JM;Lowenstein, DH
齿状颗粒细胞轴突(杂乱纤维)的重组是人类颞叶癫痫病理变化的一个突出方面。虽然最近的工作已经开始解决杂乱的纤维重组的重要性，但这些网络变化的具体和总体功能后果仍然知之甚少。新的研究开始为这一过程的分子机制提供洞察力。我们对乱糟糟的纤维重组的原因和影响的了解的进展可能有助于深入了解颞叶癫痫的病理生理学，以及神经系统损伤后的网络重建这一更大的问题。
Reorganization of dentate granule cell axons (messy fibers) is a prominent aspect of the pathological changes observed in human temporal lobe epilepsy. Although recent work has begun to address the significance of messy fiber reorganization, the specific and overall functional consequences of these network changes remain poorly understood. New studies are beginning to provide insight into molecular mechanisms underlying this process. Advances in our understanding of the causes and effects of messy fiber reorganization are likely to provide insight into the pathophysiology of temporal lobe epilepsy, as well as the larger issue of network remodeling following nervous system injury.