Mast cell synapses and exosomes: membrane contacts for information exchange.
Mast cell synapses and exosomes: membrane contacts for information exchange.
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DOI：
10.3389/fimmu.2012.00046
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发表时间：
2012
影响因子：
7.3
通讯作者：
Wilson BS
中科院分区：
文献类型：
--
作者：
Carroll-Portillo A;Surviladze Z;Cambi A;Lidke DS;Wilson BS
除了在变态反应中的中心作用外，肥大细胞还参与稳态和疾病期间的各种细胞相互作用。在这篇综述中，我们讨论了肥大细胞的能力，以扩大其机制的细胞间通信超出了可溶性介质的释放。这些包括在抗原呈递表面上形成肥大细胞突触，以及与树突细胞和T细胞的细胞-细胞接触。膜结合的外泌体的释放还提供抗原、肥大细胞蛋白和RNA向其它白细胞的转移。随着对肥大细胞在免疫调节过程中广泛作用的认识，有必要进一步研究肥大细胞参与的过程。这重新打开肥大细胞研究令人兴奋的可能性，证明它是一个免疫学前沿。
In addition to their central role in allergy, mast cells are involved in a wide variety of cellular interactions during homeostasis and disease. In this review, we discuss the ability of mast cells to extend their mechanisms for intercellular communication beyond the release of soluble mediators. These include formation of mast cell synapses on antigen presenting surfaces, as well as cell–cell contacts with dendritic cells and T cells. Release of membrane bound exosomes also provide for the transfer of antigen, mast cell proteins, and RNA to other leukocytes. With the recognition of the extended role mast cells have during immune modulation, further investigation of the processes in which mast cells are involved is necessary. This reopens mast cell research to exciting possibilities, demonstrating it to be an immunological frontier.