Evaluating dermal myelinated nerve fibers in skin biopsy.
Evaluating dermal myelinated nerve fibers in skin biopsy.
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DOI：
10.1002/mus.23510
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发表时间：
2013-01
期刊：
影响因子：
3.4
通讯作者：
Li, Jun
中科院分区：
文献类型：
--
作者：
Myers, M. Iliza;Peltier, Amanda C.;Li, Jun
关键词：
虽然对皮肤中细小的无髓鞘纤维进行了广泛的研究，但很少有研究对真皮有髓鞘纤维进行比较。无毛、无毛的皮肤含有机械感受器，为观察有髓鞘纤维提供了有利条件，而以前只有通过侵入性神经活检才能观察到。本文综述了目前通过对皮肤髓鞘纤维的各种处理和分析方法获得的规范性和致病性无毛皮肤的形态学和分子表达数据。最近的出版物阐明了无毛皮肤活检在识别周围神经病变体征中的作用，并作为远端髓鞘和机械受体完整性的潜在生物标志物。更好地理解真皮髓鞘神经终止在周围神经病变中的作用的临床意义，将根据最近在皮肤活检领域不断增长的出版物来解决。
Although there has been extensive research on small, unmyelinated fibers in the skin, little research has investigated dermal myelinated fibers in comparison. Glabrous, non-hairy skin contains mechanoreceptors that afford a vantage point for observation of myelinated fibers that have previously been seen only with invasively obtained nerve biopsies. This review discusses current morphometric and molecular expression data of normative and pathogenic glabrous skin obtained by various processing and analysis methods for cutaneous myelinated fibers. Recent publications have shed light on the role of glabrous skin biopsy in identifying signs of peripheral neuropathy and as a potential biomarker of distal myelin and mechanoreceptor integrity. The clinical relevance of a better understanding of the role of dermal myelinated nerve terminations in peripheral neuropathy will be addressed in light of recent publications in the growing field of skin biopsy.
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影响因子：
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通讯作者：
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影响因子：
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