Developmental differences in hippocampal and cortical contributions to episodic retrieval
Developmental differences in hippocampal and cortical contributions to episodic retrieval
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DOI：
10.1016/j.cortex.2012.08.004
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发表时间：
2013-06-01
期刊：
影响因子：
3.6
通讯作者：
Ghetti, Simona
中科院分区：
文献类型：
--
作者：
DeMaster, Dana M.;Ghetti, Simona
情景记忆，即形成和提取关于特定过去事件的有意识记忆的能力，在儿童时期会得到提高。先前的成人神经影像学结果表明海马体在情景提取中起着核心作用，但尚不清楚海马体的作用在发育过程中是否会发生变化。传统上，情景提取能力在发育过程中的提高被认为取决于前额叶皮质（PFC）所介导的策略性过程，该区域被认为相对于海马体具有较长的发育过程。本研究的主要目的是检验情景提取能力的发展是否也与海马体功能的变化相关这一假设。8至11岁的儿童和18至25岁的成人（N = 41）对周围有绿色或红色边框的黑白线条画进行编码。在参与者试图回忆每种图画最初搭配的颜色时，获取了功能性磁共振成像（fMRI）数据。正确回忆物品 - 颜色配对表明情景提取成功。在成人中，前海马体（而非后海马体）的活动与情景提取相关，而在儿童中，后海马体（而非前海马体）的活动与情景提取相关。在前外侧前额叶皮质和后顶叶皮质区域也发现了发育差异。总体而言，这些结果支持这样一种观点，即情景记忆的发展得到了海马体以及其他关键皮质区域功能变化的支持。（C）2012爱思唯尔有限公司。保留所有权利。
Episodic memory, or the ability to form and retrieve conscious memories about specific past events, improves during childhood. Previous adult neuroimaging results indicate a central role of the hippocampus in episodic retrieval, but it is not clear whether the contribution of the hippocampus changes during development. Traditionally, developmental improvements in episodic retrieval have been thought to depend on strategic processes mediated by the prefrontal cortex (PFC), a region that is considered to have a protracted course of development relative to the hippocampus. The primary goal of the present study was to test the hypothesis that the development of episodic retrieval is also associated with changes in hippocampal function. Children ages 8- to 11-years-old and adults ages 18-25 (N = 41) encoded black and white line drawings surrounded by either a green or red border. Functional magnetic resonance imaging (fMRI) data were acquired while participants attempted to recall which colour was originally paired with each drawing. Correct recall of item-colour pairings indicated successful episodic retrieval. Activity in the anterior hippocampus, but not in the posterior hippocampus, was associated with episodic retrieval in adults, whereas activity in the posterior, but not in the anterior hippocampus, was associated with episodic retrieval in children. Developmental differences were also found in regions in anterior lateral PFC and posterior parietal cortex. Overall, these results support the view that the development of episodic memory is supported by functional changes in the hippocampus as well as in other critical cortical regions. (C) 2012 Elsevier Ltd. All rights reserved.