Psychiatric disorders in individuals with methamphetamine dependence: prevalence and risk factors
Psychiatric disorders in individuals with methamphetamine dependence: prevalence and risk factors
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DOI：
10.1007/s11011-014-9496-5
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发表时间：
2014-06-01
影响因子：
3.6
通讯作者：
Stein, Dan J.
中科院分区：
文献类型：
--
作者：
Akindipe, Taiwo;Wilson, Don;Stein, Dan J.
甲基苯丙胺依赖可能与一系列精神障碍有关。然而，相对较少的研究系统地研究了这些障碍和可能的危险因素。这项研究使用结构化的诊断性访谈来评估甲基苯丙胺依赖者合并精神障碍的患病率和模式；并确定这种共病的危险因素。从三个戒毒中心连续招募了100名被诊断为甲基苯丙胺依赖且没有共病疾病的成年志愿者。每个志愿者都接受了社会人口调查问卷的评估，并使用DSM-IV轴I障碍结构化临床访谈(SCID-I)进行了精神共病评估。回归模型被用来确定精神共病的预测因素。36.0%的样本存在共病精神障碍，包括情绪障碍(16.0%)、精神障碍(13.0%)和焦虑症(7.0%)。这些疾病中有四分之一被评估为是由物质引起的。男性(OR=10.0 4，95%C.I=2.0 7~48.63，p=0.004)、年轻(OR=0.87，95%C.I=0.77~0.99，P=0.0 4)和既往有精神障碍史(OR=18.45，95%C.I=3.81~89.33，P=0.001)是精神疾病共病的独立预测因素。情绪、精神病和焦虑症在甲基苯丙胺依赖者中很常见。这种共病的危险因素是可以确定的。这些发现强调了需要一种综合的护理模式来解决物质使用障碍和精神共病。
Methamphetamine dependence may be associated with a range of psychiatric disorders. However, relatively few studies have systematically examined these disorders and possible risk factors. This study used a structured diagnostic interview to assess the prevalence and pattern of co-morbid psychiatric disorders in individuals with methamphetamine dependence; and identified risk factors for this comorbidity. One hundred adult volunteers with a diagnosis of methamphetamine dependence and without co-morbid medical disorders were consecutively recruited from three drug rehabilitation centres. Each volunteer was assessed with a socio-demographic questionnaire and evaluated for psychiatric comorbidity using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I). A regression model was used to determine predictors of psychiatric comorbidity. Co-morbid psychiatric disorders were present in 36.0 % of the sample; these included mood disorders (16.0 %), psychotic disorders (13.0 %) and anxiety disorders (7.0 %). One in four of these disorders were assessed as being substance-induced. Independent predictors of psychiatric comorbidity included being male (OR = 10.04, 95 % C.I = 2.07-48.63, p = 0.004), younger (OR = 0.87, 95 % C.I = 0.77-0.99, p = 0.04), and having a previous psychiatric disorder (OR = 18.45, 95 % C.I = 3.81-89.33, p < 0.001). Mood, psychotic, and anxiety disorders are common in individuals with methamphetamine dependence. Risk factors for such comorbidity can be identified. These findings underscore the need for an integrated model of care addressing both substance use disorders and psychiatric comorbidity.